Chlorthalidone has 7 known drug interactions based on U.S. FDA drug labeling data. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Lithium, Acidifying Agents, Adrenergic Blockers. Patients taking Chlorthalidone should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 7
- Major
- 1
- Moderate
- 6
Major (1)
- Chlorthalidone + Lithium— Chlorthalidone reduces lithium renal clearance, increasing the risk of lithium toxicity. Monitor serum lithium levels du…
Moderate (6)
- Chlorthalidone + Acidifying Agents— Higher dosages of oral hypoglycemic agents may be required during chlorthalidone administration due to altered glucose c…
- Chlorthalidone + Adrenergic Blockers— Chlorthalidone potentiates the action of ganglionic peripheral adrenergic blocking drugs, increasing antihypertensive ef…
- Chlorthalidone + Digitalis Glycosides— Digitalis may influence serum electrolytes when used with chlorthalidone, requiring monitoring for warning signs of elec…
- Chlorthalidone + Insulin Human— Chlorthalidone may alter insulin requirements in diabetic patients; requirements may be increased, decreased, or unchang…
- Chlorthalidone + Norepinephrine— Chlorthalidone may decrease arterial responsiveness to norepinephrine, though this does not preclude its therapeutic eff…
- Chlorthalidone + Tubocurarine— Chlorthalidone may increase the responsiveness to tubocurarine, potentially enhancing its neuromuscular blocking effects…