Chlorthalidone reduces lithium renal clearance, increasing the risk of lithium toxicity. Monitor serum lithium levels during concomitant use.
Source: NLP:chlorthalidone
Chlorthalidone Interactions
Brand names: Chlorthalidone
Thiazide-like Diuretic
Route: Oral
Contraindications
CONTRAINDICATIONS Anuria. Known hypersensitivity to chlorthalidone or other sulfonamide-derived drugs.
Pregnancy & Breastfeeding
Pregnancy Teratogenic Effects. Pregnancy Category B Reproduction studies have been performed in the rat and the rabbit at doses up to 420 times the human dose and have revealed no evidence of harm to the fetus due to chlorthalidone. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Nonteratogenic Effects Thiazides cross the placental barrier and appear in cord blood. The use of chlorthalidone and related drugs in pregnant women requires that the anticipated benefits of the drug be weighed against possible hazards to the fetus. These hazards include fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in the adult.
7 interactions on record
Higher dosages of oral hypoglycemic agents may be required during chlorthalidone administration due to altered glucose control.
Source: NLP:chlorthalidone
Chlorthalidone potentiates the action of ganglionic peripheral adrenergic blocking drugs, increasing antihypertensive effects.
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Digitalis may influence serum electrolytes when used with chlorthalidone, requiring monitoring for warning signs of electrolyte imbalance.
Source: NLP:chlorthalidone
Chlorthalidone + Insulin HumanModerate
Chlorthalidone may alter insulin requirements in diabetic patients; requirements may be increased, decreased, or unchanged.
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Chlorthalidone + NorepinephrineModerate
Chlorthalidone may decrease arterial responsiveness to norepinephrine, though this does not preclude its therapeutic effectiveness as a pressor agent.
Source: NLP:chlorthalidone
Chlorthalidone + TubocurarineModerate
Chlorthalidone may increase the responsiveness to tubocurarine, potentially enhancing its neuromuscular blocking effects.
Source: NLP:chlorthalidone