Chlorzoxazone has 3 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Lemborexant, Methylergonovine, Methylergonovine Maleate. Patients taking Chlorzoxazone should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 3
Moderate: 3

Moderate (3)

Chlorzoxazone + Lemborexant— Weak CYP3A inhibitor that increases lemborexant AUC and Cmax. Maximum recommended dose of lemborexant is 5 mg when used …
Chlorzoxazone + Methylergonovine— Weak CYP 3A4 inhibitor; should be administered with caution.
Chlorzoxazone + Methylergonovine Maleate— Weak CYP 3A4 inhibitor; should be administered with caution due to potential vasospasm risk.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.