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Chlorzoxazone

Also known as: Lorzone

3 interactions on record

Chlorzoxazone has 3 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Lemborexant, Methylergonovine, Methylergonovine Maleate. Patients taking Chlorzoxazone should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 3
Moderate: 3

Moderate (3)

Chlorzoxazone + Lemborexant— Weak CYP3A inhibitor that increases lemborexant AUC and Cmax. Maximum recommended dose of lemborexant is 5 mg when used …
Chlorzoxazone + Methylergonovine— Weak CYP 3A4 inhibitor; should be administered with caution.
Chlorzoxazone + Methylergonovine Maleate— Weak CYP 3A4 inhibitor; should be administered with caution due to potential vasospasm risk.

Chlorzoxazone + Lemborexant🟡Moderate

Weak CYP3A inhibitor that increases lemborexant AUC and Cmax. Maximum recommended dose of lemborexant is 5 mg when used concomitantly.

Chlorzoxazone + Methylergonovine🟡Moderate

Weak CYP 3A4 inhibitor; should be administered with caution.

Chlorzoxazone + Methylergonovine Maleate🟡Moderate

Weak CYP 3A4 inhibitor; should be administered with caution due to potential vasospasm risk.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.