Erythromycin Lactobionate has 16 known drug interactions based on U.S. FDA drug labeling data. Of these, 4 are contraindicated combinations that should be avoided entirely. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Dihydroergotamine, Ergotamine, Lovastatin. Patients taking Erythromycin Lactobionate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 16
- Contraindicated
- 4
- Major
- 4
- Moderate
- 7
Contraindicated (4)
- Erythromycin Lactobionate + Dihydroergotamine— Co-administration associated with acute ergot toxicity characterized by vasospasm and ischemia of central nervous system…
- Erythromycin Lactobionate + Ergotamine— Co-administration associated with acute ergot toxicity characterized by vasospasm and ischemia of central nervous system…
- Erythromycin Lactobionate + Lovastatin— Increased risk of myopathy, including rhabdomyolysis when used with erythromycin due to CYP3A4 metabolism inhibition.
- Erythromycin Lactobionate + Simvastatin— Increased risk of myopathy, including rhabdomyolysis when used with erythromycin due to CYP3A4 metabolism inhibition.
Major (4)
- Erythromycin Lactobionate + Astemizole— Erythromycin significantly alters metabolism of this nonsedating antihistamine; rare serious cardiovascular adverse even…
- Erythromycin Lactobionate + Carbamazepine— Erythromycin increases serum carbamazepine levels with subsequent development of carbamazepine toxicity signs.
- Erythromycin Lactobionate + Terfenadine— Erythromycin significantly alters metabolism of this nonsedating antihistamine; rare serious cardiovascular adverse even…
- Erythromycin Lactobionate + Theophylline— May increase serum theophylline levels and cause potential toxicity. Concomitant use may also decrease erythromycin seru…
Moderate (7)
- Erythromycin Lactobionate + Colchicine— Significant increase in colchicine plasma concentration anticipated; dosage reduction may be necessary and colchicine to…
- Erythromycin Lactobionate + Digoxin— Concomitant use may result in elevated serum digoxin levels.
- Erythromycin Lactobionate + Erythromycin— Drug Interactions Erythromycin administration in patients receiving 3-hydroxy-3-methylglutaryl-coenzyme A (HMG CoA) redu…
- Erythromycin Lactobionate + Midazolam— Erythromycin decreases clearance and may increase pharmacological effect of midazolam.
- Erythromycin Lactobionate + Sildenafil— Increased systemic exposure (AUC) of sildenafil reported; dosage reduction should be considered.
- Erythromycin Lactobionate + Triazolam— Erythromycin decreases clearance and may increase pharmacological effect of triazolam.
- Erythromycin Lactobionate + Warfarin— Increased anticoagulant effects may occur, potentially more pronounced in elderly patients.