Voclosporin has 12 known drug interactions based on U.S. FDA drug labeling data. Of these, 3 are contraindicated combinations that should be avoided entirely. 6 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Clarithromycin, Itraconazole, Ketoconazole. Patients taking Voclosporin should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 12
- Contraindicated
- 3
- Major
- 6
- Moderate
- 3
Contraindicated (3)
- Voclosporin + Clarithromycin— Co-administration of LUPKYNIS with strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin) is contra…
- Voclosporin + Itraconazole— Co-administration of LUPKYNIS with strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin) is contra…
- Voclosporin + Ketoconazole— Co-administration of LUPKYNIS with strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin) is contra…
Major (6)
- Voclosporin + Atorvastatin— OATP1B1/OATP1B3 substrate; voclosporin increases exposure. Monitor for myopathy and rhabdomyolysis; reduce dosage as rec…
- Voclosporin + Fluvastatin— OATP1B1/OATP1B3 substrate; voclosporin increases exposure. Monitor for myopathy and rhabdomyolysis; reduce dosage as rec…
- Voclosporin + Pitavastatin— OATP1B1/OATP1B3 substrate; voclosporin increases exposure. Monitor for myopathy and rhabdomyolysis; reduce dosage as rec…
- Voclosporin + Pravastatin— OATP1B1/OATP1B3 substrate; voclosporin increases exposure. Monitor for myopathy and rhabdomyolysis; reduce dosage as rec…
- Voclosporin + Rosuvastatin— OATP1B1/OATP1B3 substrate; voclosporin increases exposure. Monitor for myopathy and rhabdomyolysis; reduce dosage as rec…
- Voclosporin + Simvastatin— OATP1B1 substrate; voclosporin increases simvastatin acid exposure 3.1-fold (Cmax) and 1.8-fold (AUC). Monitor for myopa…
Moderate (3)
- Voclosporin + Diltiazem— Moderate CYP3A4 inhibitor that increases voclosporin exposure; dosage reduction of voclosporin required.
- Voclosporin + Fluconazole— Reduce LUPKYNIS dosage when co-administered with moderate CYP3A4 inhibitors (e.g., verapamil, fluconazole, diltiazem) [s…
- Voclosporin + Verapamil— Moderate CYP3A4 inhibitor that increases voclosporin exposure; dosage reduction of voclosporin required.