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Glimepiride

Also known as: Glimepiride

Sulfonylurea

Route: Oral

67 interactions on record

Glimepiride has 67 known drug interactions based on U.S. FDA drug labeling data. 6 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Ciprofloxacin, Ciprofloxacin Hydrochloride, Ciprofloxacin Tablets. Patients taking Glimepiride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 67
Major: 6
Moderate: 61

Major (6)

Glimepiride + Ciprofloxacin— Co-administration may cause severe hypoglycemia and fatalities have been reported due to potentiation of glucose-lowerin…
Glimepiride + Ciprofloxacin Hydrochloride— Concomitant use potentiates glucose-lowering effect, with severe hypoglycemia and fatalities reported. Monitor blood glu…
Glimepiride + Ciprofloxacin Tablets— Co-administration may cause severe hypoglycemia and fatalities have been reported due to potentiation of glucose-lowerin…
Glimepiride + Colesevelam Hydrochloride— Colesevelam may decrease sulfonylurea exposure. Administer glimepiride 4 hours prior to colesevelam.
Glimepiride + Fluconazole— Inhibits metabolism of glimepiride, causing increased plasma concentrations and risk of severe hypoglycemia. Monitor clo…
Glimepiride + Miconazole— Miconazole: Severe hypoglycemia can occur when glimepiride and oral miconazole are used concomitantly. 7.2 Miconazole A …

Moderate (61)

Glimepiride + Acetazolamide— Highly protein-bound drugs that may increase glucose-lowering effect of glimepiride, increasing susceptibility to hypogl…
Glimepiride + Albuterol— Sympathomimetic that may reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.
Glimepiride + Alcohol— Both acute and chronic alcohol intake may potentiate or weaken the glucose-lowering action of glimepiride in an unpredic…
Glimepiride + Anakinra— May increase glucose-lowering effect of glimepiride, increasing susceptibility to hypoglycemia.
Glimepiride + Androgens— May increase glucose-lowering effect of glimepiride, increasing susceptibility to hypoglycemia.
Glimepiride + Barbiturates— May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.
Glimepiride + Chloramphenicol— Highly protein-bound drug that may increase glucose-lowering effect of glimepiride, increasing susceptibility to hypogly…
Glimepiride + Clarithromycin— May increase glucose-lowering effect of glimepiride, increasing susceptibility to and/or intensity of hypoglycemia.
Glimepiride + Clonidine— May lead to either potentiation or weakening of glimepiride's glucose-lowering effect. May also reduce signs of hypoglyc…
Glimepiride + Clozapine— Atypical antipsychotic that may reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.
Glimepiride + Colesevelam— Coadministration may reduce glimepiride absorption. Glimepiride should be administered at least 4 hours prior to colesev…
Glimepiride + Corticosteroids— May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.
Glimepiride + Cyclophosphamide— May increase glucose-lowering effect of glimepiride, increasing susceptibility to and/or intensity of hypoglycemia.
Glimepiride + Danazol— May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.
Glimepiride + Diazoxide— May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.
Glimepiride + Disopyramide— May increase glucose-lowering effect of glimepiride, increasing susceptibility to and/or intensity of hypoglycemia.
Glimepiride + Diuretics— May reduce the glucose-lowering effect of glimepiride, leading to worsening glycemic control.
Glimepiride + Elexacaftor, Tezacaftor, And Ivacaftor— TRIKAFTA may increase glimepiride exposure via CYP2C9 inhibition. Use with caution and monitor.
Glimepiride + Enalapril— ACE inhibitor may increase glucose-lowering effect of glimepiride, increasing susceptibility to hypoglycemia.
Glimepiride + Epinephrine— Sympathomimetic that may reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.
Glimepiride + Estrogens— May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.
Glimepiride + Fibrates— May increase glucose-lowering effect of glimepiride, increasing susceptibility to hypoglycemia.
Glimepiride + Fluoxetine— Highly protein-bound drug that may increase glucose-lowering effect of glimepiride, increasing susceptibility to hypogly…
Glimepiride + Glucagon— May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.
Glimepiride + Guanethidine— May increase glucose-lowering effect of glimepiride, increasing susceptibility to and/or intensity of hypoglycemia.
Glimepiride + Ibuprofen— NSAID that may increase glucose-lowering effect of glimepiride, increasing susceptibility to hypoglycemia.
Glimepiride + Insulin Human— May increase glucose-lowering effect of glimepiride, increasing susceptibility to and/or intensity of hypoglycemia.
Glimepiride + Isoniazid— May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.
Glimepiride + Ivacaftor— Ivacaftor may increase glimepiride exposure through CYP2C9 inhibition. Should be used with caution.
Glimepiride + Laxatives— May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.
Glimepiride + Mao Inhibitors— May increase glucose-lowering effect of glimepiride, increasing susceptibility to hypoglycemia.
Glimepiride + Monoamine Oxidase Inhibitors (Maois)— May increase glucose-lowering effect of glimepiride, increasing susceptibility to hypoglycemia.
Glimepiride + Niacin— May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.
Glimepiride + Nonselective Beta-Adrenergic Antagonists— May lead to either potentiation or weakening of glimepiride's glucose-lowering effect. May also reduce signs of hypoglyc…
Glimepiride + Nonsteroidal Anti-Inflammatory Drugs (Nsaids)— Highly protein-bound; may increase glucose-lowering effect of glimepiride, increasing susceptibility to hypoglycemia.
Glimepiride + Nsaids— May increase the glucose-lowering effect of glimepiride due to high protein binding, increasing susceptibility to hypogl…
Glimepiride + Olanzapine— Atypical antipsychotic that may reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.
Glimepiride + Oral Anticoagulants— Highly protein-bound drugs that may increase glucose-lowering effect of glimepiride, increasing susceptibility to hypogl…
Glimepiride + Oral Contraceptives— May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.
Glimepiride + Pentoxifylline— May increase glucose-lowering effect of glimepiride, increasing susceptibility to and/or intensity of hypoglycemia.
Glimepiride + Phenothiazines— May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.
Glimepiride + Phenytoin— May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.
Glimepiride + Pramlintide— May increase the glucose-lowering effect of glimepiride, increasing susceptibility to hypoglycemia.
Glimepiride + Pramlintide Acetate— May increase glucose-lowering effect of glimepiride, increasing susceptibility to and/or intensity of hypoglycemia.
Glimepiride + Probenecid— Highly protein-bound drug that may increase glucose-lowering effect of glimepiride, increasing susceptibility to hypogly…
Glimepiride + Propoxyphene— May increase glucose-lowering effect of glimepiride, increasing susceptibility to and/or intensity of hypoglycemia.
Glimepiride + Protease Inhibitors— May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.
Glimepiride + Quinolone— May increase glucose-lowering effect of glimepiride, increasing susceptibility to and/or intensity of hypoglycemia.
Glimepiride + Reserpine— May lead to either potentiation or weakening of glimepiride's glucose-lowering effect.
Glimepiride + Rifampin— May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.
Glimepiride + Salicylates— Highly protein-bound drugs that may increase glucose-lowering effect of glimepiride, increasing susceptibility to hypogl…
Glimepiride + Somatostatin— May increase glucose-lowering effect of glimepiride, increasing susceptibility to hypoglycemia.
Glimepiride + Somatropin— May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.
Glimepiride + Sulfinpyrazone— May increase glucose-lowering effect of glimepiride, increasing susceptibility to and/or intensity of hypoglycemia.
Glimepiride + Terbutaline— Sympathomimetic that may reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.
Glimepiride + Tetracycline— May increase glucose-lowering effect of glimepiride, increasing susceptibility to and/or intensity of hypoglycemia.
Glimepiride + Thiazides— May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.
Glimepiride + Thyroid Hormones— May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.
Glimepiride + Topical Steroids— May increase glucose-lowering effect of glimepiride, increasing susceptibility to hypoglycemia.
Glimepiride + Vorinostat— May increase glucose-lowering effect of glimepiride, increasing susceptibility to and/or intensity of hypoglycemia.
Glimepiride + Warfarin— Coumarin anticoagulant that may increase glucose-lowering effect of glimepiride, increasing susceptibility to hypoglycem…

Glimepiride + Ciprofloxacin⚠️Major

Co-administration may cause severe hypoglycemia and fatalities have been reported due to potentiation of glucose-lowering effect.

Glimepiride + Ciprofloxacin Hydrochloride⚠️Major

Concomitant use potentiates glucose-lowering effect, with severe hypoglycemia and fatalities reported. Monitor blood glucose.

Glimepiride + Ciprofloxacin Tablets⚠️Major

Co-administration may cause severe hypoglycemia and fatalities have been reported due to potentiation of glucose-lowering effect.

Glimepiride + Colesevelam Hydrochloride⚠️Major

Colesevelam may decrease sulfonylurea exposure. Administer glimepiride 4 hours prior to colesevelam.

Glimepiride + Fluconazole⚠️Major

Inhibits metabolism of glimepiride, causing increased plasma concentrations and risk of severe hypoglycemia. Monitor closely.

Glimepiride + Miconazole⚠️Major

Miconazole: Severe hypoglycemia can occur when glimepiride and oral miconazole are used concomitantly. 7.2 Miconazole A potential interaction between oral miconazole and sulfonylureas leading to severe hypoglycemia has been reported. Whether this interaction also occurs with other dosage forms of miconazole is not known.

Glimepiride + Acetazolamide🟡Moderate

Highly protein-bound drugs that may increase glucose-lowering effect of glimepiride, increasing susceptibility to hypoglycemia.

Glimepiride + Albuterol🟡Moderate

Sympathomimetic that may reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.

Glimepiride + Alcohol🟡Moderate

Both acute and chronic alcohol intake may potentiate or weaken the glucose-lowering action of glimepiride in an unpredictable fashion.

Glimepiride + Anakinra🟡Moderate

May increase glucose-lowering effect of glimepiride, increasing susceptibility to hypoglycemia.

Glimepiride + Androgens🟡Moderate

May increase glucose-lowering effect of glimepiride, increasing susceptibility to hypoglycemia.

Glimepiride + Barbiturates🟡Moderate

May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.

Glimepiride + Chloramphenicol🟡Moderate

Highly protein-bound drug that may increase glucose-lowering effect of glimepiride, increasing susceptibility to hypoglycemia.

Glimepiride + Clarithromycin🟡Moderate

May increase glucose-lowering effect of glimepiride, increasing susceptibility to and/or intensity of hypoglycemia.

Glimepiride + Clonidine🟡Moderate

May lead to either potentiation or weakening of glimepiride's glucose-lowering effect. May also reduce signs of hypoglycemia.

Glimepiride + Clozapine🟡Moderate

Atypical antipsychotic that may reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.

Glimepiride + Colesevelam🟡Moderate

Coadministration may reduce glimepiride absorption. Glimepiride should be administered at least 4 hours prior to colesevelam.

Glimepiride + Corticosteroids🟡Moderate

May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.

Glimepiride + Cyclophosphamide🟡Moderate

May increase glucose-lowering effect of glimepiride, increasing susceptibility to and/or intensity of hypoglycemia.

Glimepiride + Danazol🟡Moderate

May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.

Glimepiride + Diazoxide🟡Moderate

May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.

Glimepiride + Disopyramide🟡Moderate

May increase glucose-lowering effect of glimepiride, increasing susceptibility to and/or intensity of hypoglycemia.

Glimepiride + Diuretics🟡Moderate

May reduce the glucose-lowering effect of glimepiride, leading to worsening glycemic control.

Glimepiride + Elexacaftor, Tezacaftor, And Ivacaftor🟡Moderate

TRIKAFTA may increase glimepiride exposure via CYP2C9 inhibition. Use with caution and monitor.

Glimepiride + Enalapril🟡Moderate

ACE inhibitor may increase glucose-lowering effect of glimepiride, increasing susceptibility to hypoglycemia.

Glimepiride + Epinephrine🟡Moderate

Sympathomimetic that may reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.

Glimepiride + Estrogens🟡Moderate

May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.

Glimepiride + Fibrates🟡Moderate

May increase glucose-lowering effect of glimepiride, increasing susceptibility to hypoglycemia.

Glimepiride + Fluoxetine🟡Moderate

Highly protein-bound drug that may increase glucose-lowering effect of glimepiride, increasing susceptibility to hypoglycemia.

Glimepiride + Glucagon🟡Moderate

May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.

Glimepiride + Guanethidine🟡Moderate

May increase glucose-lowering effect of glimepiride, increasing susceptibility to and/or intensity of hypoglycemia.

Glimepiride + Ibuprofen🟡Moderate

NSAID that may increase glucose-lowering effect of glimepiride, increasing susceptibility to hypoglycemia.

Glimepiride + Insulin Human🟡Moderate

May increase glucose-lowering effect of glimepiride, increasing susceptibility to and/or intensity of hypoglycemia.

Glimepiride + Isoniazid🟡Moderate

May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.

Glimepiride + Ivacaftor🟡Moderate

Ivacaftor may increase glimepiride exposure through CYP2C9 inhibition. Should be used with caution.

Glimepiride + Laxatives🟡Moderate

May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.

Glimepiride + Mao Inhibitors🟡Moderate

May increase glucose-lowering effect of glimepiride, increasing susceptibility to hypoglycemia.

Glimepiride + Monoamine Oxidase Inhibitors (Maois)🟡Moderate

May increase glucose-lowering effect of glimepiride, increasing susceptibility to hypoglycemia.

Glimepiride + Niacin🟡Moderate

May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.

Glimepiride + Nonselective Beta-Adrenergic Antagonists🟡Moderate

May lead to either potentiation or weakening of glimepiride's glucose-lowering effect. May also reduce signs of hypoglycemia.

Glimepiride + Nonsteroidal Anti-Inflammatory Drugs (Nsaids)🟡Moderate

Highly protein-bound; may increase glucose-lowering effect of glimepiride, increasing susceptibility to hypoglycemia.

Glimepiride + Nsaids🟡Moderate

May increase the glucose-lowering effect of glimepiride due to high protein binding, increasing susceptibility to hypoglycemia.

Glimepiride + Olanzapine🟡Moderate

Atypical antipsychotic that may reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.

Glimepiride + Oral Anticoagulants🟡Moderate

Highly protein-bound drugs that may increase glucose-lowering effect of glimepiride, increasing susceptibility to hypoglycemia.

Glimepiride + Oral Contraceptives🟡Moderate

May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.

Glimepiride + Pentoxifylline🟡Moderate

May increase glucose-lowering effect of glimepiride, increasing susceptibility to and/or intensity of hypoglycemia.

Glimepiride + Phenothiazines🟡Moderate

May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.

Glimepiride + Phenytoin🟡Moderate

May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.

Glimepiride + Pramlintide🟡Moderate

May increase the glucose-lowering effect of glimepiride, increasing susceptibility to hypoglycemia.

Glimepiride + Pramlintide Acetate🟡Moderate

May increase glucose-lowering effect of glimepiride, increasing susceptibility to and/or intensity of hypoglycemia.

Glimepiride + Probenecid🟡Moderate

Highly protein-bound drug that may increase glucose-lowering effect of glimepiride, increasing susceptibility to hypoglycemia.

Glimepiride + Propoxyphene🟡Moderate

May increase glucose-lowering effect of glimepiride, increasing susceptibility to and/or intensity of hypoglycemia.

Glimepiride + Protease Inhibitors🟡Moderate

May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.

Glimepiride + Quinolone🟡Moderate

May increase glucose-lowering effect of glimepiride, increasing susceptibility to and/or intensity of hypoglycemia.

Glimepiride + Reserpine🟡Moderate

May lead to either potentiation or weakening of glimepiride's glucose-lowering effect.

Glimepiride + Rifampin🟡Moderate

May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.

Glimepiride + Salicylates🟡Moderate

Highly protein-bound drugs that may increase glucose-lowering effect of glimepiride, increasing susceptibility to hypoglycemia.

Glimepiride + Somatostatin🟡Moderate

May increase glucose-lowering effect of glimepiride, increasing susceptibility to hypoglycemia.

Glimepiride + Somatropin🟡Moderate

May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.

Glimepiride + Sulfinpyrazone🟡Moderate

May increase glucose-lowering effect of glimepiride, increasing susceptibility to and/or intensity of hypoglycemia.

Glimepiride + Terbutaline🟡Moderate

Sympathomimetic that may reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.

Glimepiride + Tetracycline🟡Moderate

May increase glucose-lowering effect of glimepiride, increasing susceptibility to and/or intensity of hypoglycemia.

Glimepiride + Thiazides🟡Moderate

May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.

Glimepiride + Thyroid Hormones🟡Moderate

May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.

Glimepiride + Topical Steroids🟡Moderate

May increase glucose-lowering effect of glimepiride, increasing susceptibility to hypoglycemia.

Glimepiride + Vorinostat🟡Moderate

May increase glucose-lowering effect of glimepiride, increasing susceptibility to and/or intensity of hypoglycemia.

Glimepiride + Warfarin🟡Moderate

Coumarin anticoagulant that may increase glucose-lowering effect of glimepiride, increasing susceptibility to hypoglycemia.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.