Exemestane has 6 known drug interactions based on U.S. FDA drug labeling data. 5 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Carbamazepine, Phenobarbital, Phenytoin. Patients taking Exemestane should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 6
- Major
- 5
- Minor
- 1
Major (5)
- Exemestane + Carbamazepine— Strong CYP 3A4 inducer that significantly decreases exemestane exposure. Dose increase to 50 mg recommended.
- Exemestane + Phenobarbital— Strong CYP 3A4 inducer that significantly decreases exemestane exposure. Dose increase to 50 mg recommended.
- Exemestane + Phenytoin— Strong CYP 3A4 inducer that significantly decreases exemestane exposure. Dose increase to 50 mg recommended.
- Exemestane + Rifampin— Strong CYP 3A4 inducer that significantly decreases exemestane exposure. Dose increase to 50 mg recommended.
- Exemestane + St. John'S Wort— Strong CYP 3A4 inducer that significantly decreases exemestane exposure. Dose increase to 50 mg recommended.
Minor (1)
- Exemestane + Ketoconazole— Potent CYP 3A4 inhibitor with no significant effect on exemestane pharmacokinetics in clinical study.