Clofibrate has 11 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Dantrolene, Dantrolene Sodium, Levothyroxine Sodium. Patients taking Clofibrate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 11
- Moderate
- 11
Moderate (11)
- Clofibrate + Dantrolene— Clofibrate reduces binding of dantrolene to plasma proteins, potentially increasing free drug concentration.
- Clofibrate + Dantrolene Sodium— Clofibrate reduces dantrolene binding to plasma proteins, potentially affecting dantrolene levels and efficacy.
- Clofibrate + Levothyroxine Sodium— May increase serum thyroxine-binding globulin concentration, resulting in initial transient increase in FT4 followed by …
- Clofibrate + Liothyronine Sodium— May increase serum thyroxine-binding globulin concentration, altering T3 serum transport without affecting free thyroxin…
- Clofibrate + Norelgestromin And Ethinyl Estradiol— CHCs have been shown to decrease plasma concentrations of clofibric acid.
- Clofibrate + Norethindrone Acetate, Ethinyl Estradiol And Ferrous Fumarate— Oral contraceptives may induce conjugation of clofibric acid, increasing its clearance.
- Clofibrate + Norethindrone Acetate/Ethinyl Estradiol— Oral contraceptives may induce conjugation of clofibric acid, increasing its clearance and decreasing plasma concentrati…
- Clofibrate + Norgestimate And Ethinyl Estradiol— Norgestimate and ethinyl estradiol may decrease plasma concentrations of clofibrate.
- Clofibrate + Ursodiol— Increases hepatic cholesterol secretion and may counteract the effectiveness of ursodiol.
- Clofibrate + Ursosiol— Increases hepatic cholesterol secretion and encourages cholesterol gallstone formation, potentially counteracting ursodi…
- Clofibrate + Usodiol— Lipid-lowering drug that increases hepatic cholesterol secretion and encourages cholesterol gallstone formation, counter…