Clomipramine

10 interactions on record

Clomipramine has 10 known drug interactions based on U.S. FDA drug labeling data. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Dexmethylphenidate Hydrochloride, Methylene Blue, Norepinephrine Bitartrate. Patients taking Clomipramine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 10
Major: 3
Moderate: 7

Major (3)

Clomipramine + Dexmethylphenidate Hydrochloride— Methylphenidate may inhibit the metabolism of clomipramine. Downward dose adjustments may be required and plasma drug co…
Clomipramine + Methylene Blue— Concomitant use may result in serotonin syndrome with serious CNS reactions, potentially fatal.
Clomipramine + Norepinephrine Bitartrate— Co-administration can cause severe, prolonged hypertension. Monitor for hypertension if norepinephrine bitartrate cannot…

Moderate (7)

Clomipramine + Armodafinil— Elimination of clomipramine may be prolonged by armodafinil via inhibition of metabolic enzymes, resulting in higher sys…
Clomipramine + Methylphenidate— Methylphenidate may inhibit metabolism of this tricyclic drug. Downward dose adjustments may be required and plasma conc…
Clomipramine + Methylphenidate Hydrochloride— Methylphenidate may inhibit metabolism of clomipramine. Downward dosage adjustments may be required.
Clomipramine + Metoprolol— Potent CYP2D6 inhibitor may increase plasma concentration of metoprolol, decreasing cardioselectivity.
Clomipramine + Metoprolol Tartrate— Potent CYP2D6 inhibitor may increase metoprolol plasma concentration, decreasing cardioselectivity.
Clomipramine + Milnacipran Hydrochloride— Drug-drug interaction study showed increase in euphoria and postural hypotension in patients who switched to SAVELLA.
Clomipramine + Modafinil— Elimination may be prolonged by modafinil with resultant higher systemic exposure. Dose adjustment may be necessary when…

Clomipramine + Dexmethylphenidate Hydrochloride⚠️Major

Methylphenidate may inhibit the metabolism of clomipramine. Downward dose adjustments may be required and plasma drug concentration should be monitored.

Clomipramine + Methylene Blue⚠️Major

Concomitant use may result in serotonin syndrome with serious CNS reactions, potentially fatal.

Clomipramine + Norepinephrine Bitartrate⚠️Major

Co-administration can cause severe, prolonged hypertension. Monitor for hypertension if norepinephrine bitartrate cannot be avoided.

Clomipramine + Armodafinil🟡Moderate

Elimination of clomipramine may be prolonged by armodafinil via inhibition of metabolic enzymes, resulting in higher systemic exposure. Dose reduction may be required.

Clomipramine + Methylphenidate🟡Moderate

Methylphenidate may inhibit metabolism of this tricyclic drug. Downward dose adjustments may be required and plasma concentrations should be monitored.

Clomipramine + Methylphenidate Hydrochloride🟡Moderate

Methylphenidate may inhibit metabolism of clomipramine. Downward dosage adjustments may be required.

Clomipramine + Metoprolol🟡Moderate

Potent CYP2D6 inhibitor may increase plasma concentration of metoprolol, decreasing cardioselectivity.

Clomipramine + Metoprolol Tartrate🟡Moderate

Potent CYP2D6 inhibitor may increase metoprolol plasma concentration, decreasing cardioselectivity.

Clomipramine + Milnacipran Hydrochloride🟡Moderate

Drug-drug interaction study showed increase in euphoria and postural hypotension in patients who switched to SAVELLA.

Clomipramine + Modafinil🟡Moderate

Elimination may be prolonged by modafinil with resultant higher systemic exposure. Dose adjustment may be necessary when used concomitantly.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.