Butyrophenones has 24 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Cabergoline, Bromocriptine Mesylate, Clonazepam. Patients taking Butyrophenones should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 24
- Contraindicated
- 1
- Major
- 3
- Moderate
- 20
Contraindicated (1)
- Butyrophenones + Cabergoline— Cabergoline should not be administered concurrently with butyrophenones, which are D2-antagonists that may antagonize ca…
Major (3)
- Butyrophenones + Bromocriptine Mesylate— Dopamine receptor antagonists may diminish the effectiveness of bromocriptine, and bromocriptine may diminish their effe…
- Butyrophenones + Clonazepam— Potentiates CNS-depressant action of clonazepam.
- Butyrophenones + Ropinirole— Dopamine antagonists may diminish the effectiveness of ropinirole. Use in patients with major psychotic disorders only i…
Moderate (20)
- Butyrophenones + Articaine Hydrochloride And Epinephrine— May reduce or reverse the pressor effect of epinephrine; concurrent use should be avoided but careful monitoring is esse…
- Butyrophenones + Articaine Hydrochloride And Epinephrine Bitartrate— May reduce or reverse the pressor effect of epinephrine; concurrent use should generally be avoided but if necessary req…
- Butyrophenones + Bupivacaine Hydrochloride— May reduce or reverse the pressor effect of epinephrine in local anesthetic solutions.
- Butyrophenones + Bupivacaine Hydrochloride And Epinephrine Bitartrate— May reduce or reverse the pressor effect of epinephrine. Concurrent use should generally be avoided; if necessary, caref…
- Butyrophenones + Carbidopa— Dopamine D2 receptor antagonists may reduce the therapeutic effects of levodopa; patients should be carefully observed f…
- Butyrophenones + Carbidopa And Levodopa— Dopamine D2 receptor antagonists may reduce the therapeutic effects of levodopa; patients should be carefully observed f…
- Butyrophenones + Carbidopa Tablets— Dopamine D2 receptor antagonists may reduce therapeutic effects of levodopa; patients should be carefully observed for l…
- Butyrophenones + Carbidopa, Levodopa And Entacapone— Dopamine D2 receptor antagonists may reduce therapeutic effects of levodopa.
- Butyrophenones + Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine— Butyrophenones may reduce or reverse the pressor effect of epinephrine; concurrent use should generally be avoided and r…
- Butyrophenones + Foscarbidopa/Foslevodopa— Dopamine D2 receptor antagonist may reduce effectiveness of foslevodopa. Monitor for worsening Parkinson's symptoms.
- Butyrophenones + Levodopa— Butyrophenones (dopamine D2 receptor antagonists) may reduce the effectiveness of levodopa. Monitor patients for worseni…
- Butyrophenones + Lidocaine Hydrochloride— May reduce or reverse the pressor effect of epinephrine in lidocaine solutions; concurrent use should generally be avoid…
- Butyrophenones + Lidocaine Hydrochloride And Epinephrine Bitartrate— May reduce or reverse pressor effect of epinephrine. Concurrent use should generally be avoided; careful patient monitor…
- Butyrophenones + Marcaine, Lidocaine, Kenalog, Povidone Iodine— Butyrophenones may reduce or reverse the pressor effect of epinephrine. Concurrent use should generally be avoided.
- Butyrophenones + Mepivacaine Hydrochloride— May reduce or reverse the pressor effect of epinephrine in mepivacaine solutions.
- Butyrophenones + Pramipexole— Dopamine antagonists may diminish the effectiveness of pramipexole.
- Butyrophenones + Pramipexole Dihydrochloride— Dopamine antagonists may diminish the effectiveness of pramipexole dihydrochloride.
- Butyrophenones + Ropinirole Hydrochloride— Neuroleptic dopamine antagonists that may reduce the efficacy of ropinirole tablets.
- Butyrophenones + Sodium Hyaluronate, Lidocaine, Isopropyl Alcohol— Butyrophenones may reduce or reverse the pressor effect of epinephrine. Concurrent use should generally be avoided; care…
- Butyrophenones + Triamcinolone Acetonide— May reduce or reverse the pressor effect of epinephrine in local anesthetic solutions. Concurrent use should generally b…