Mixed Agonist/Antagonist Opioid Analgesics Interactions

Concomitant use may reduce analgesic effect and/or precipitate withdrawal symptoms. Avoid concomitant use.

Source: NLP:hydromorphone hydrochloride

May reduce analgesic effect of morphine and/or precipitate withdrawal symptoms. Concomitant use should be avoided.

Source: NLP:morphine sulfate

May reduce analgesic effect of oxycodone or precipitate withdrawal symptoms. Avoid concomitant use.

Source: NLP:oxycodone hydrochloride

May reduce analgesic effect of oxymorphone or precipitate withdrawal symptoms.

Source: NLP:oxymorphone hydrochloride

May reduce analgesic effect and/or precipitate withdrawal symptoms. Careful observation during treatment initiation and dose adjustment recommended.

Source: NLP:remifentanil hydrochloride

May reduce the analgesic effect of tapentadol and/or precipitate withdrawal symptoms.

Source: NLP:tapentadol hydrochloride