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Oxycodone Hydrochloride Oral Solution

Also known as: Oxycodone Hydrochloride Oral Solution

Route: Oral

Check Oxycodone Hydrochloride Oral Solution Interactions →

9 interactions on record⛔ Black Box Warning

Oxycodone Hydrochloride Oral Solution has 9 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 6 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Alcohol, Nitrazepam, Carbamazepine. Patients taking Oxycodone Hydrochloride Oral Solution should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 9
Contraindicated: 2
Major: 6

Contraindicated (2)

Oxycodone Hydrochloride Oral Solution + Alcohol— CNS depressant that increases risk of respiratory depression, profound sedation, coma, and death due to additive pharmac…
Oxycodone Hydrochloride Oral Solution + Nitrazepam— Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depress…

Major (6)

Oxycodone Hydrochloride Oral Solution + Carbamazepine— CYP3A4 inducer that decreases oxycodone plasma concentration, resulting in decreased efficacy or withdrawal syndrome. Up…
Oxycodone Hydrochloride Oral Solution + Erythromycin— CYP3A4 inhibitor that increases oxycodone plasma concentration, resulting in increased or prolonged opioid effects inclu…
Oxycodone Hydrochloride Oral Solution + Ketoconazole— Azole-antifungal CYP3A4 inhibitor that increases oxycodone plasma concentration, resulting in increased or prolonged opi…
Oxycodone Hydrochloride Oral Solution + Phenytoin— CYP3A4 inducer that decreases oxycodone plasma concentration, resulting in decreased efficacy or withdrawal syndrome. Up…
Oxycodone Hydrochloride Oral Solution + Rifampin— CYP3A4 inducer that decreases oxycodone plasma concentration, resulting in decreased efficacy or withdrawal syndrome. Up…
Oxycodone Hydrochloride Oral Solution + Ritonavir— Protease inhibitor and CYP3A4 inhibitor that increases oxycodone plasma concentration, resulting in increased or prolong…

Oxycodone Hydrochloride Oral Solution + Alcohol⛔Contraindicated

CNS depressant that increases risk of respiratory depression, profound sedation, coma, and death due to additive pharmacologic effects.

Oxycodone Hydrochloride Oral Solution + Nitrazepam⛔Contraindicated

Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depressant effects.

Oxycodone Hydrochloride Oral Solution + Carbamazepine⚠️Major

CYP3A4 inducer that decreases oxycodone plasma concentration, resulting in decreased efficacy or withdrawal syndrome. Upon discontinuation, increased oxycodone levels may cause serious respiratory depression.

Oxycodone Hydrochloride Oral Solution + Erythromycin⚠️Major

CYP3A4 inhibitor that increases oxycodone plasma concentration, resulting in increased or prolonged opioid effects including respiratory depression and sedation.

Oxycodone Hydrochloride Oral Solution + Ketoconazole⚠️Major

Azole-antifungal CYP3A4 inhibitor that increases oxycodone plasma concentration, resulting in increased or prolonged opioid effects including respiratory depression and sedation.

Oxycodone Hydrochloride Oral Solution + Phenytoin⚠️Major

Oxycodone Hydrochloride Oral Solution + Rifampin⚠️Major

Oxycodone Hydrochloride Oral Solution + Ritonavir⚠️Major

Protease inhibitor and CYP3A4 inhibitor that increases oxycodone plasma concentration, resulting in increased or prolonged opioid effects including respiratory depression and sedation.

Oxycodone Hydrochloride Oral Solution + Oxycodoneℹ️Unknown

7 DRUG INTERACTIONS Table 1 includes clinically significant drug interactions with Oxycodone Hydrochloride Oral Solution. Table 1: Clinically Significant Drug Interactions with Oxycodone Hydrochloride Oral Solution Inhibitors of CYP3A4 and CYP2D6 Clinical Impact: The concomitant use of Oxycodone Hydrochloride Oral Solution and CYP3A4 inhibitors can increase the plasma concentration of oxycodone, resulting in increased or prolonged opioid effects. These effects could be more pronounced with concomitant use of Oxycodone Hydrochloride Oral Solution and CYP2D6 and CYP3A4 inhibitors, particularly when an inhibitor is added after a stable dose of Oxycodone Hydrochloride Oral Solution is achieved [see Warnings and Precautions (5.6) ].

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.