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Lidocaine Hydrochloride And Epinephrine Bitartrate

Also known as: Lidocaine

alpha-Adrenergic Agonistbeta-Adrenergic AgonistCatecholamine

Route: Submucosal

Check Lidocaine Hydrochloride And Epinephrine Bitartrate Interactions →

41 interactions on record

Lidocaine Hydrochloride And Epinephrine Bitartrate has 41 known drug interactions based on U.S. FDA drug labeling data. 38 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Acetaminophen, Acetazolamide, Articaine. Patients taking Lidocaine Hydrochloride And Epinephrine Bitartrate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 41
Major: 38
Moderate: 3

Major (38)

Lidocaine Hydrochloride And Epinephrine Bitartrate + Acetaminophen— Associated with increased methemoglobinemia risk when used concurrently with local anesthetics.
Lidocaine Hydrochloride And Epinephrine Bitartrate + Acetazolamide— Antibiotic associated with increased methemoglobinemia risk when used concurrently.
Lidocaine Hydrochloride And Epinephrine Bitartrate + Articaine— Local anesthetic associated with increased methemoglobinemia risk when used concurrently.
Lidocaine Hydrochloride And Epinephrine Bitartrate + Benzocaine— Local anesthetic associated with increased methemoglobinemia risk when used concurrently.
Lidocaine Hydrochloride And Epinephrine Bitartrate + Bupivacaine— Local anesthetic associated with increased methemoglobinemia risk when used concurrently.
Lidocaine Hydrochloride And Epinephrine Bitartrate + Chloroquine— Antimalarial associated with increased methemoglobinemia risk when used concurrently.
Lidocaine Hydrochloride And Epinephrine Bitartrate + Cyclophosphamide— Examples of Drugs Associated with Methemoglobinemia: Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitro…
Lidocaine Hydrochloride And Epinephrine Bitartrate + Dapsone— Antibiotic associated with increased methemoglobinemia risk when used concurrently.
Lidocaine Hydrochloride And Epinephrine Bitartrate + Ergot-Type Oxytocic Drugs— Concurrent administration may cause severe, persistent hypertension or cerebrovascular accidents.
Lidocaine Hydrochloride And Epinephrine Bitartrate + Flutamide— Examples of Drugs Associated with Methemoglobinemia: Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitro…
Lidocaine Hydrochloride And Epinephrine Bitartrate + Hydroxyurea— Antineoplastic agent associated with increased methemoglobinemia risk when used concurrently.
Lidocaine Hydrochloride And Epinephrine Bitartrate + Ifosfamide— Examples of Drugs Associated with Methemoglobinemia: Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitro…
Lidocaine Hydrochloride And Epinephrine Bitartrate + Mepivacaine— Local anesthetic associated with increased methemoglobinemia risk when used concurrently.
Lidocaine Hydrochloride And Epinephrine Bitartrate + Metoclopramide— Examples of Drugs Associated with Methemoglobinemia: Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitro…
Lidocaine Hydrochloride And Epinephrine Bitartrate + Monoamine Oxidase Inhibitors (Maois)— May produce severe prolonged hypotension or hypertension. Concurrent use should generally be avoided; careful monitoring…
Lidocaine Hydrochloride And Epinephrine Bitartrate + Nitric Oxide— Associated with methemoglobinemia risk when concurrent exposure occurs with local anesthetics.
Lidocaine Hydrochloride And Epinephrine Bitartrate + Nitrofurantoin— Antibiotic associated with increased methemoglobinemia risk when used concurrently.
Lidocaine Hydrochloride And Epinephrine Bitartrate + Nitroglycerin— Associated with methemoglobinemia risk when concurrent exposure occurs with local anesthetics.
Lidocaine Hydrochloride And Epinephrine Bitartrate + Nitroprusside— Associated with methemoglobinemia risk when concurrent exposure occurs with local anesthetics.
Lidocaine Hydrochloride And Epinephrine Bitartrate + Nitrous Oxide— Associated with methemoglobinemia risk when concurrent exposure occurs with local anesthetics.
Lidocaine Hydrochloride And Epinephrine Bitartrate + Nonselective Beta-Adrenergic Antagonists— May cause severe hypertension and bradycardia with possible heart block. Concurrent use should generally be avoided.
Lidocaine Hydrochloride And Epinephrine Bitartrate + Para-Aminosalicylic Acid— Antibiotic associated with increased methemoglobinemia risk when used concurrently.
Lidocaine Hydrochloride And Epinephrine Bitartrate + Phenobarbital— Anticonvulsant associated with increased methemoglobinemia risk when used concurrently.
Lidocaine Hydrochloride And Epinephrine Bitartrate + Phenothiazines— May produce severe prolonged hypotension or hypertension. Concurrent use should generally be avoided; careful monitoring…
Lidocaine Hydrochloride And Epinephrine Bitartrate + Phenytoin— Anticonvulsant associated with increased methemoglobinemia risk when used concurrently.
Lidocaine Hydrochloride And Epinephrine Bitartrate + Prilocaine— Local anesthetic associated with increased methemoglobinemia risk when used concurrently.
Lidocaine Hydrochloride And Epinephrine Bitartrate + Primaquine— Antimalarial associated with increased methemoglobinemia risk when used concurrently.
Lidocaine Hydrochloride And Epinephrine Bitartrate + Procaine— Local anesthetic associated with increased methemoglobinemia risk when used concurrently.
Lidocaine Hydrochloride And Epinephrine Bitartrate + Propranolol— May result in dose-dependent hypertension and bradycardia with possible heart block.
Lidocaine Hydrochloride And Epinephrine Bitartrate + Quinine— Associated with increased methemoglobinemia risk when used concurrently with local anesthetics.
Lidocaine Hydrochloride And Epinephrine Bitartrate + Rasburicase— Antineoplastic agent associated with increased methemoglobinemia risk when used concurrently.
Lidocaine Hydrochloride And Epinephrine Bitartrate + Ropivacaine— Local anesthetic associated with increased methemoglobinemia risk when used concurrently.
Lidocaine Hydrochloride And Epinephrine Bitartrate + Sulfasalazine— Associated with increased methemoglobinemia risk when used concurrently with local anesthetics.
Lidocaine Hydrochloride And Epinephrine Bitartrate + Tetracaine— Local anesthetic associated with increased methemoglobinemia risk when used concurrently.
Lidocaine Hydrochloride And Epinephrine Bitartrate + Timolol— May result in dose-dependent hypertension and bradycardia with possible heart block.
Lidocaine Hydrochloride And Epinephrine Bitartrate + Topical Local Anesthetics— Serious dose-related cardiac arrhythmias may occur when epinephrine-containing preparations are used during or following…
Lidocaine Hydrochloride And Epinephrine Bitartrate + Valproate Sodium— Anticonvulsant associated with increased methemoglobinemia risk when used concurrently.
Lidocaine Hydrochloride And Epinephrine Bitartrate + Vasopressin— Concurrent administration may cause severe, persistent hypertension or cerebrovascular accidents.

Moderate (3)

Lidocaine Hydrochloride And Epinephrine Bitartrate + Butyrophenones— May reduce or reverse pressor effect of epinephrine. Concurrent use should generally be avoided; careful patient monitor…
Lidocaine Hydrochloride And Epinephrine Bitartrate + Nitrates— Increased risk of developing methemoglobinemia when concurrently exposed.
Lidocaine Hydrochloride And Epinephrine Bitartrate + Nitrites— Increased risk of developing methemoglobinemia when concurrently exposed.

Lidocaine Hydrochloride And Epinephrine Bitartrate + Acetaminophen⚠️Major

Associated with increased methemoglobinemia risk when used concurrently with local anesthetics.

Lidocaine Hydrochloride And Epinephrine Bitartrate + Acetazolamide⚠️Major

Antibiotic associated with increased methemoglobinemia risk when used concurrently.

Lidocaine Hydrochloride And Epinephrine Bitartrate + Articaine⚠️Major

Local anesthetic associated with increased methemoglobinemia risk when used concurrently.

Lidocaine Hydrochloride And Epinephrine Bitartrate + Benzocaine⚠️Major

Local anesthetic associated with increased methemoglobinemia risk when used concurrently.

Lidocaine Hydrochloride And Epinephrine Bitartrate + Bupivacaine⚠️Major

Local anesthetic associated with increased methemoglobinemia risk when used concurrently.

Lidocaine Hydrochloride And Epinephrine Bitartrate + Chloroquine⚠️Major

Antimalarial associated with increased methemoglobinemia risk when used concurrently.

Lidocaine Hydrochloride And Epinephrine Bitartrate + Cyclophosphamide⚠️Major

Examples of Drugs Associated with Methemoglobinemia: Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitroprusside, nitrous oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, isofamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine 7.6 Potent Inhalation Anesthetics Serious dose-related cardiac arrhythmias may occur if preparations containing epinephrine are used in patients during or following the administration of potent inhalation anesthetics [see Warnings and Precautions (5.10) ] .

Lidocaine Hydrochloride And Epinephrine Bitartrate + Dapsone⚠️Major

Antibiotic associated with increased methemoglobinemia risk when used concurrently.

Lidocaine Hydrochloride And Epinephrine Bitartrate + Ergot-Type Oxytocic Drugs⚠️Major

Concurrent administration may cause severe, persistent hypertension or cerebrovascular accidents.

Lidocaine Hydrochloride And Epinephrine Bitartrate + Flutamide⚠️Major

Lidocaine Hydrochloride And Epinephrine Bitartrate + Hydroxyurea⚠️Major

Antineoplastic agent associated with increased methemoglobinemia risk when used concurrently.

Lidocaine Hydrochloride And Epinephrine Bitartrate + Ifosfamide⚠️Major

Lidocaine Hydrochloride And Epinephrine Bitartrate + Mepivacaine⚠️Major

Local anesthetic associated with increased methemoglobinemia risk when used concurrently.

Lidocaine Hydrochloride And Epinephrine Bitartrate + Metoclopramide⚠️Major

Lidocaine Hydrochloride And Epinephrine Bitartrate + Monoamine Oxidase Inhibitors (Maois)⚠️Major

May produce severe prolonged hypotension or hypertension. Concurrent use should generally be avoided; careful monitoring essential if necessary.

Lidocaine Hydrochloride And Epinephrine Bitartrate + Nitric Oxide⚠️Major

Associated with methemoglobinemia risk when concurrent exposure occurs with local anesthetics.

Lidocaine Hydrochloride And Epinephrine Bitartrate + Nitrofurantoin⚠️Major

Antibiotic associated with increased methemoglobinemia risk when used concurrently.

Lidocaine Hydrochloride And Epinephrine Bitartrate + Nitroglycerin⚠️Major

Associated with methemoglobinemia risk when concurrent exposure occurs with local anesthetics.

Lidocaine Hydrochloride And Epinephrine Bitartrate + Nitroprusside⚠️Major

Associated with methemoglobinemia risk when concurrent exposure occurs with local anesthetics.

Lidocaine Hydrochloride And Epinephrine Bitartrate + Nitrous Oxide⚠️Major

Associated with methemoglobinemia risk when concurrent exposure occurs with local anesthetics.

Lidocaine Hydrochloride And Epinephrine Bitartrate + Nonselective Beta-Adrenergic Antagonists⚠️Major

May cause severe hypertension and bradycardia with possible heart block. Concurrent use should generally be avoided.

Lidocaine Hydrochloride And Epinephrine Bitartrate + Para-Aminosalicylic Acid⚠️Major

Antibiotic associated with increased methemoglobinemia risk when used concurrently.

Lidocaine Hydrochloride And Epinephrine Bitartrate + Phenobarbital⚠️Major

Anticonvulsant associated with increased methemoglobinemia risk when used concurrently.

Lidocaine Hydrochloride And Epinephrine Bitartrate + Phenothiazines⚠️Major

May produce severe prolonged hypotension or hypertension. Concurrent use should generally be avoided; careful monitoring essential if necessary.

Lidocaine Hydrochloride And Epinephrine Bitartrate + Phenytoin⚠️Major

Anticonvulsant associated with increased methemoglobinemia risk when used concurrently.

Lidocaine Hydrochloride And Epinephrine Bitartrate + Prilocaine⚠️Major

Local anesthetic associated with increased methemoglobinemia risk when used concurrently.

Lidocaine Hydrochloride And Epinephrine Bitartrate + Primaquine⚠️Major

Antimalarial associated with increased methemoglobinemia risk when used concurrently.

Lidocaine Hydrochloride And Epinephrine Bitartrate + Procaine⚠️Major

Local anesthetic associated with increased methemoglobinemia risk when used concurrently.

Lidocaine Hydrochloride And Epinephrine Bitartrate + Propranolol⚠️Major

May result in dose-dependent hypertension and bradycardia with possible heart block.

Lidocaine Hydrochloride And Epinephrine Bitartrate + Quinine⚠️Major

Associated with increased methemoglobinemia risk when used concurrently with local anesthetics.

Lidocaine Hydrochloride And Epinephrine Bitartrate + Rasburicase⚠️Major

Antineoplastic agent associated with increased methemoglobinemia risk when used concurrently.

Lidocaine Hydrochloride And Epinephrine Bitartrate + Ropivacaine⚠️Major

Local anesthetic associated with increased methemoglobinemia risk when used concurrently.

Lidocaine Hydrochloride And Epinephrine Bitartrate + Sulfasalazine⚠️Major

Associated with increased methemoglobinemia risk when used concurrently with local anesthetics.

Lidocaine Hydrochloride And Epinephrine Bitartrate + Tetracaine⚠️Major

Local anesthetic associated with increased methemoglobinemia risk when used concurrently.

Lidocaine Hydrochloride And Epinephrine Bitartrate + Timolol⚠️Major

May result in dose-dependent hypertension and bradycardia with possible heart block.

Lidocaine Hydrochloride And Epinephrine Bitartrate + Topical Local Anesthetics⚠️Major

Serious dose-related cardiac arrhythmias may occur when epinephrine-containing preparations are used during or following potent inhalation anesthetics.

Lidocaine Hydrochloride And Epinephrine Bitartrate + Valproate Sodium⚠️Major

Anticonvulsant associated with increased methemoglobinemia risk when used concurrently.

Lidocaine Hydrochloride And Epinephrine Bitartrate + Vasopressin⚠️Major

Concurrent administration may cause severe, persistent hypertension or cerebrovascular accidents.

Lidocaine Hydrochloride And Epinephrine Bitartrate + Butyrophenones🟡Moderate

May reduce or reverse pressor effect of epinephrine. Concurrent use should generally be avoided; careful patient monitoring essential if necessary.

Lidocaine Hydrochloride And Epinephrine Bitartrate + Nitrates🟡Moderate

Increased risk of developing methemoglobinemia when concurrently exposed.

Lidocaine Hydrochloride And Epinephrine Bitartrate + Nitrites🟡Moderate

Increased risk of developing methemoglobinemia when concurrently exposed.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.