Metformin Hydrochloride Tablet has 21 known drug interactions based on U.S. FDA drug labeling data. 8 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Acetazolamide, Cimetidine, Dichlorphenamide. Patients taking Metformin Hydrochloride Tablet should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 21
- Major
- 8
- Moderate
- 13
Major (8)
- Metformin Hydrochloride Tablet + Acetazolamide— Carbonic anhydrase inhibitor that decreases serum bicarbonate and may increase risk for lactic acidosis when used with m…
- Metformin Hydrochloride Tablet + Cimetidine— Reduces metformin clearance via OCT2/MATE inhibition, increasing systemic exposure and risk of lactic acidosis.
- Metformin Hydrochloride Tablet + Dichlorphenamide— Carbonic anhydrase inhibitor that decreases serum bicarbonate and may increase risk for lactic acidosis when used with m…
- Metformin Hydrochloride Tablet + Dolutegravir— Reduces metformin clearance via OCT2/MATE inhibition, increasing systemic exposure and risk of lactic acidosis.
- Metformin Hydrochloride Tablet + Ranolazine— Reduces metformin clearance via OCT2/MATE inhibition, increasing systemic exposure and risk of lactic acidosis.
- Metformin Hydrochloride Tablet + Topiramate— Carbonic anhydrase inhibitor that decreases serum bicarbonate and may increase risk for lactic acidosis when used with m…
- Metformin Hydrochloride Tablet + Vandetanib— Reduces metformin clearance via OCT2/MATE inhibition, increasing systemic exposure and risk of lactic acidosis.
- Metformin Hydrochloride Tablet + Zonisamide— Carbonic anhydrase inhibitor that decreases serum bicarbonate and may increase risk for lactic acidosis when used with m…
Moderate (13)
- Metformin Hydrochloride Tablet + Alcohol— Potentiates metformin's effect on lactate metabolism, increasing risk for lactic acidosis with excessive intake.
- Metformin Hydrochloride Tablet + Calcium Channel Blockers— May produce hyperglycemia and lead to loss of glycemic control when used with metformin.
- Metformin Hydrochloride Tablet + Corticosteroids— May produce hyperglycemia and lead to loss of glycemic control when used with metformin.
- Metformin Hydrochloride Tablet + Estrogens— May produce hyperglycemia and lead to loss of glycemic control when used with metformin.
- Metformin Hydrochloride Tablet + Insulin Human— Coadministration with metformin may increase risk of hypoglycemia requiring dose reduction.
- Metformin Hydrochloride Tablet + Isoniazid— May produce hyperglycemia and lead to loss of glycemic control when used with metformin.
- Metformin Hydrochloride Tablet + Niacin— May produce hyperglycemia and lead to loss of glycemic control when used with metformin.
- Metformin Hydrochloride Tablet + Oral Contraceptives— May produce hyperglycemia and lead to loss of glycemic control when used with metformin.
- Metformin Hydrochloride Tablet + Phenothiazines— May produce hyperglycemia and lead to loss of glycemic control when used with metformin.
- Metformin Hydrochloride Tablet + Phenytoin— May produce hyperglycemia and lead to loss of glycemic control when used with metformin.
- Metformin Hydrochloride Tablet + Sulfonylurea— Insulin secretagogue that when combined with metformin may increase risk of hypoglycemia.
- Metformin Hydrochloride Tablet + Thiazides— Diuretic that may produce hyperglycemia and lead to loss of glycemic control with metformin.
- Metformin Hydrochloride Tablet + Thyroid— May produce hyperglycemia and lead to loss of glycemic control when used with metformin.