Sodium Phenylacetate And Sodium Benzoate has 4 known drug interactions based on U.S. FDA drug labeling data. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Valproic Acid, Corticosteroids, Penicillin. Patients taking Sodium Phenylacetate And Sodium Benzoate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 4
- Major
- 1
- Moderate
- 3
Major (1)
- Sodium Phenylacetate And Sodium Benzoate + Valproic Acid— May exacerbate urea cycle disorder and antagonize efficacy by inhibiting N-acetylglutamate synthesis, a cofactor for car…
Moderate (3)
- Sodium Phenylacetate And Sodium Benzoate + Corticosteroids— May cause protein catabolism and potentially increase plasma ammonia levels in patients with impaired urea formation abi…
- Sodium Phenylacetate And Sodium Benzoate + Penicillin— May compete with phenylacetylglutamine and hippurate for active renal tubular secretion, affecting overall disposition o…
- Sodium Phenylacetate And Sodium Benzoate + Probenecid— Inhibits renal transport of organic compounds and may affect renal excretion of phenylacetylglutamine and hippurate.