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Leflunomide And Diclofenac Sodium Gel

Also known as: Lefluniclo

Route: Topical

Check Leflunomide And Diclofenac Sodium Gel Interactions →

29 interactions on record⛔ Black Box Warning

Leflunomide And Diclofenac Sodium Gel has 29 known drug interactions based on U.S. FDA drug labeling data. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Acetylsalicylic Acid, Warfarin, Alosetron. Patients taking Leflunomide And Diclofenac Sodium Gel should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 29
Major: 2
Moderate: 23

Major (2)

Leflunomide And Diclofenac Sodium Gel + Acetylsalicylic Acid— Concomitant use associated with significantly increased incidence of GI adverse reactions and increased risk of bleeding…
Leflunomide And Diclofenac Sodium Gel + Warfarin— Synergistic effect on bleeding with increased risk of serious bleeding compared to either drug alone.

Moderate (23)

Leflunomide And Diclofenac Sodium Gel + Alosetron— Exposure of alosetron may be reduced in patients taking leflunomide. Monitor and adjust dose as required.
Leflunomide And Diclofenac Sodium Gel + Atorvastatin— For other substrates of BCRP (e.g., mitoxantrone) and drugs in the OATP family (e.g., methotrexate, rifampin), especiall…
Leflunomide And Diclofenac Sodium Gel + Cefaclor— Exposure of cefaclor may be increased in patients taking leflunomide. Monitor and adjust dose as required.
Leflunomide And Diclofenac Sodium Gel + Cimetidine— Exposure of cimetidine may be increased in patients taking leflunomide. Monitor and adjust dose as required.
Leflunomide And Diclofenac Sodium Gel + Ciprofloxacin— Exposure of ciprofloxacin may be increased in patients taking leflunomide. Monitor and adjust dose as required.
Leflunomide And Diclofenac Sodium Gel + Duloxetine— Exposure of duloxetine may be reduced in patients taking leflunomide. Monitor and adjust dose as required.
Leflunomide And Diclofenac Sodium Gel + Ethinyl Estradiol— Teriflunomide may increase systemic exposure of ethinylestradiol. Consider contraceptive type or dose adjustment.
Leflunomide And Diclofenac Sodium Gel + Furosemide— NSAIDs reduce the natriuretic effect of loop diuretics. Monitor for reduced diuretic efficacy.
Leflunomide And Diclofenac Sodium Gel + Ketoprofen— Exposure of ketoprofen may be increased in patients taking leflunomide. Monitor and adjust dose as required.
Leflunomide And Diclofenac Sodium Gel + Levonorgestrel— Teriflunomide may increase systemic exposure of levonorgestrel. Consider contraceptive type or dose adjustment.
Leflunomide And Diclofenac Sodium Gel + Methotrexate— Exposure of methotrexate may be increased in patients taking leflunomide. Monitor and adjust dose as required.
Leflunomide And Diclofenac Sodium Gel + Paclitaxel— Exposure of paclitaxel may be increased in patients taking leflunomide. Monitor and adjust dose as required.
Leflunomide And Diclofenac Sodium Gel + Penicillin G— Exposure of penicillin G may be increased in patients taking leflunomide. Monitor and adjust dose as required.
Leflunomide And Diclofenac Sodium Gel + Pioglitazone— Exposure of pioglitazone may be increased in patients taking leflunomide. Monitor and adjust dose as required.
Leflunomide And Diclofenac Sodium Gel + Pravastatin— For other substrates of BCRP (e.g., mitoxantrone) and drugs in the OATP family (e.g., methotrexate, rifampin), especiall…
Leflunomide And Diclofenac Sodium Gel + Propranolol— May diminish antihypertensive effect. In elderly, volume-depleted, or renal impairment patients, may result in deteriora…
Leflunomide And Diclofenac Sodium Gel + Repaglinide— Exposure of repaglinide may be increased in patients taking leflunomide. Monitor and adjust dose as required.
Leflunomide And Diclofenac Sodium Gel + Rifampin— Rifampin, a potent CYP inducer, increased plasma concentration of teriflunomide (leflunomide's active metabolite) by 40%…
Leflunomide And Diclofenac Sodium Gel + Rosiglitazone— Exposure of rosiglitazone may be increased in patients taking leflunomide. Monitor and adjust dose as required.
Leflunomide And Diclofenac Sodium Gel + Simvastatin— For other substrates of BCRP (e.g., mitoxantrone) and drugs in the OATP family (e.g., methotrexate, rifampin), especiall…
Leflunomide And Diclofenac Sodium Gel + Theophylline— Exposure of theophylline may be reduced in patients taking leflunomide. Monitor and adjust dose as required.
Leflunomide And Diclofenac Sodium Gel + Tizanidine— Exposure of tizanidine may be reduced in patients taking leflunomide. Monitor and adjust dose as required.
Leflunomide And Diclofenac Sodium Gel + Zidovudine— Exposure of zidovudine may be increased in patients taking leflunomide. Monitor and adjust dose as required.

Leflunomide And Diclofenac Sodium Gel + Acetylsalicylic Acid⚠️Major

Concomitant use associated with significantly increased incidence of GI adverse reactions and increased risk of bleeding.

Leflunomide And Diclofenac Sodium Gel + Warfarin⚠️Major

Synergistic effect on bleeding with increased risk of serious bleeding compared to either drug alone.

Leflunomide And Diclofenac Sodium Gel + Alosetron🟡Moderate

Exposure of alosetron may be reduced in patients taking leflunomide. Monitor and adjust dose as required.

Leflunomide And Diclofenac Sodium Gel + Atorvastatin🟡Moderate

For other substrates of BCRP (e.g., mitoxantrone) and drugs in the OATP family (e.g., methotrexate, rifampin), especially HMG- Co reductase inhibitors (e.g., atorvastatin, nateglinide, pravastatin, repaglinide, and simvastatin), consider reducing the dose of these drugs and monitor patients closely for signs and symptoms of increased exposures to the drugs while patients are taking leflunomide tablets [see Clinical Pharmacology (12.3)].

Leflunomide And Diclofenac Sodium Gel + Cefaclor🟡Moderate

Exposure of cefaclor may be increased in patients taking leflunomide. Monitor and adjust dose as required.

Leflunomide And Diclofenac Sodium Gel + Cimetidine🟡Moderate

Exposure of cimetidine may be increased in patients taking leflunomide. Monitor and adjust dose as required.

Leflunomide And Diclofenac Sodium Gel + Ciprofloxacin🟡Moderate

Exposure of ciprofloxacin may be increased in patients taking leflunomide. Monitor and adjust dose as required.

Leflunomide And Diclofenac Sodium Gel + Duloxetine🟡Moderate

Exposure of duloxetine may be reduced in patients taking leflunomide. Monitor and adjust dose as required.

Leflunomide And Diclofenac Sodium Gel + Ethinyl Estradiol🟡Moderate

Teriflunomide may increase systemic exposure of ethinylestradiol. Consider contraceptive type or dose adjustment.

Leflunomide And Diclofenac Sodium Gel + Furosemide🟡Moderate

NSAIDs reduce the natriuretic effect of loop diuretics. Monitor for reduced diuretic efficacy.

Leflunomide And Diclofenac Sodium Gel + Ketoprofen🟡Moderate

Exposure of ketoprofen may be increased in patients taking leflunomide. Monitor and adjust dose as required.

Leflunomide And Diclofenac Sodium Gel + Levonorgestrel🟡Moderate

Teriflunomide may increase systemic exposure of levonorgestrel. Consider contraceptive type or dose adjustment.

Leflunomide And Diclofenac Sodium Gel + Methotrexate🟡Moderate

Exposure of methotrexate may be increased in patients taking leflunomide. Monitor and adjust dose as required.

Leflunomide And Diclofenac Sodium Gel + Paclitaxel🟡Moderate

Exposure of paclitaxel may be increased in patients taking leflunomide. Monitor and adjust dose as required.

Leflunomide And Diclofenac Sodium Gel + Penicillin G🟡Moderate

Exposure of penicillin G may be increased in patients taking leflunomide. Monitor and adjust dose as required.

Leflunomide And Diclofenac Sodium Gel + Pioglitazone🟡Moderate

Exposure of pioglitazone may be increased in patients taking leflunomide. Monitor and adjust dose as required.

Leflunomide And Diclofenac Sodium Gel + Pravastatin🟡Moderate

Leflunomide And Diclofenac Sodium Gel + Propranolol🟡Moderate

May diminish antihypertensive effect. In elderly, volume-depleted, or renal impairment patients, may result in deterioration of renal function.

Leflunomide And Diclofenac Sodium Gel + Repaglinide🟡Moderate

Exposure of repaglinide may be increased in patients taking leflunomide. Monitor and adjust dose as required.

Leflunomide And Diclofenac Sodium Gel + Rifampin🟡Moderate

Rifampin, a potent CYP inducer, increased plasma concentration of teriflunomide (leflunomide's active metabolite) by 40%. Caution should be used with concomitant administration.

Leflunomide And Diclofenac Sodium Gel + Rosiglitazone🟡Moderate

Exposure of rosiglitazone may be increased in patients taking leflunomide. Monitor and adjust dose as required.

Leflunomide And Diclofenac Sodium Gel + Simvastatin🟡Moderate

Leflunomide And Diclofenac Sodium Gel + Theophylline🟡Moderate

Exposure of theophylline may be reduced in patients taking leflunomide. Monitor and adjust dose as required.

Leflunomide And Diclofenac Sodium Gel + Tizanidine🟡Moderate

Exposure of tizanidine may be reduced in patients taking leflunomide. Monitor and adjust dose as required.

Leflunomide And Diclofenac Sodium Gel + Zidovudine🟡Moderate

Exposure of zidovudine may be increased in patients taking leflunomide. Monitor and adjust dose as required.

Leflunomide And Diclofenac Sodium Gel + Leflunomideℹ️Unknown

7 DRUG INTERACTIONS Following oral administration, leflunomide is metabolized to an active metabolite, teriflunomide, which is responsible for essentially all of leflunomide's in vivo activity. Drug interaction studies have been conducted with both leflunomide and with its active metabolite, teriflunomide, where the metabolite was directly administered to the test subjects. Effect of potent CYP and transporter inducers Leflunomide is metabolized by CYP450 metabolizing enzymes.

Leflunomide And Diclofenac Sodium Gel + Penicillinℹ️Unknown

In patients taking leflunomide tablets, exposure of drugs which are OAT3 substrates (e.g., cefaclor, cimetidine, ciprofloxacin, penicillin G, ketoprofen, furosemide, methotrexate, zidovudine) may be increased.

Leflunomide And Diclofenac Sodium Gel + Rosuvastatinℹ️Unknown

For a patient taking leflunomide tablets, the dose of rosuvastatin should not exceed 10 mg once daily. (7) Rosuvastatin: The dose of rosuvastatin should not exceed 10 mg once daily in patients taking leflunomide tablets.

Leflunomide And Diclofenac Sodium Gel + Teriflunomideℹ️Unknown

7 DRUG INTERACTIONS Following oral administration, leflunomide is metabolized to an active metabolite, teriflunomide, which is responsible for essentially all of leflunomide's in vivo activity. Drug interaction studies have been conducted with both leflunomide and with its active metabolite, teriflunomide, where the metabolite was directly administered to the test subjects. Concomitant use of leflunomide tablets and rifampin, a potent inducer of CYP and transporters, increased the plasma concentration of teriflunomide by 40%.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.