Zolpidem Tartrate Sublingual has 8 known drug interactions based on U.S. FDA drug labeling data. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Alcohol, Chlorpromazine, Imipramine. Patients taking Zolpidem Tartrate Sublingual should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 8
- Major
- 1
- Moderate
- 5
- Minor
- 2
Major (1)
- Zolpidem Tartrate Sublingual + Alcohol— Additive adverse effect on psychomotor performance demonstrated. Possible adverse additive CNS depressant effects.
Moderate (5)
- Zolpidem Tartrate Sublingual + Chlorpromazine— Additive effect of decreased alertness and impaired psychomotor performance observed with no pharmacokinetic interaction…
- Zolpidem Tartrate Sublingual + Imipramine— Additive effect of decreased alertness observed. 20% decrease in peak levels of imipramine with no other pharmacokinetic…
- Zolpidem Tartrate Sublingual + Ketoconazole— Potent CYP3A4 inhibitor that increased pharmacodynamic effects of zolpidem; lower dose consideration recommended.
- Zolpidem Tartrate Sublingual + Rifampin— CYP3A4 inducer that significantly reduces exposure to and pharmacodynamic effects of zolpidem, potentially decreasing ef…
- Zolpidem Tartrate Sublingual + Sertraline— Increases exposure to zolpidem and may increase the pharmacodynamic effect of zolpidem.
Minor (2)
- Zolpidem Tartrate Sublingual + Fluoxetine— Increases zolpidem half-life by 17% after multiple doses, but no evidence of additive effect on psychomotor performance.
- Zolpidem Tartrate Sublingual + Haloperidol— No effect of haloperidol on the pharmacokinetics or pharmacodynamics of zolpidem observed in single-dose study.