Home›Loop Diuretics

Loop Diuretics

22 interactions on record

Loop Diuretics has 22 known drug interactions based on U.S. FDA drug labeling data. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Foscarnet Sodium, Human Immunoglobulin G, Metolazone. Patients taking Loop Diuretics should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 22
Major: 3
Moderate: 19

Major (3)

Loop Diuretics + Foscarnet Sodium— May impair foscarnet elimination by inhibiting renal tubular secretion, potentially leading to toxicity. Thiazides recom…
Loop Diuretics + Human Immunoglobulin G— Concomitant use with IGIV may increase blood viscosity and risk of thromboembolic events. Loop diuretics should be avoid…
Loop Diuretics + Metolazone— Concomitant use can cause unusually large or prolonged losses of fluid and electrolytes.

Moderate (19)

Loop Diuretics + Albuterol— Non-potassium-sparing loop diuretics can cause ECG changes and hypokalemia that may be worsened by albuterol, especially…
Loop Diuretics + Albuterol Sulfate— Non-potassium sparing diuretics can have ECG changes and hypokalemia acutely worsened by beta-agonists, especially at ex…
Loop Diuretics + Arformoterol Tartrate— Non-potassium sparing diuretics may cause ECG changes and hypokalemia that can be worsened by beta-agonists. Use with ca…
Loop Diuretics + Dichlorphenamide— Increased risk of hypokalemia with coadministration of dichlorphenamide and loop diuretics.
Loop Diuretics + Diclofenac Sodium— NSAIDs reduced the natriuretic effect of loop diuretics.
Loop Diuretics + Dopamine Hydrochloride— Low-dose dopamine with diuretics may produce additive or potentiating effect on urine flow.
Loop Diuretics + Enalapril Maleate— Enalapril attenuates potassium loss caused by thiazide diuretics; monitor serum potassium.
Loop Diuretics + Fluticasone Furoate And Vilanterol— Electrocardiographic changes and hypokalemia may be worsened by vilanterol, especially at higher doses.
Loop Diuretics + Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate— Non-potassium-sparing diuretics may cause hypokalemia and ECG changes that can be worsened by vilanterol, especially at …
Loop Diuretics + Formoterol Fumarate Dihydrate— Non-potassium-sparing diuretics may cause hypokalemia and ECG changes that can worsen with concurrent beta-agonists. Use…
Loop Diuretics + Ipratropium Bromide And Albuterol Sulfate— Non-potassium sparing diuretics can worsen ECG changes and hypokalemia induced by β-agonists, especially at higher doses…
Loop Diuretics + Levalbuterol— May worsen ECG changes or hypokalemia. Monitor potassium levels during coadministration.
Loop Diuretics + Levalbuterol Hydrochloride— May worsen ECG changes or hypokalemia. Consider monitoring potassium levels during coadministration.
Loop Diuretics + Levalbuterol Inhalation Solution— May worsen electrocardiographic changes and hypokalemia. Monitor potassium levels during coadministration.
Loop Diuretics + Salmeterol Xinafoate— Non-potassium-sparing diuretics may have ECG changes and hypokalemia worsened by salmeterol, especially at higher doses.
Loop Diuretics + Sumatriptan Succinate And Naproxen Sodium— NSAIDs can reduce natriuretic effect of loop diuretics. Monitor diuretic efficacy including antihypertensive effects.
Loop Diuretics + Terbutaline Sulfate— Nonpotassium-sparing diuretics may cause ECG changes and hypokalemia that can be worsened by beta-agonists, especially a…
Loop Diuretics + Umeclidinium Bromide And Vilanterol Trifenatate— May worsen electrocardiographic changes and/or hypokalemia associated with non-potassium-sparing diuretics when combined…
Loop Diuretics + Zoledronic Acid— Concomitant use with zoledronic acid may increase risk of hypocalcemia. Caution should be exercised when zoledronic acid…

Loop Diuretics + Foscarnet Sodium⚠️Major

May impair foscarnet elimination by inhibiting renal tubular secretion, potentially leading to toxicity. Thiazides recommended instead.

Loop Diuretics + Human Immunoglobulin G⚠️Major

Concomitant use with IGIV may increase blood viscosity and risk of thromboembolic events. Loop diuretics should be avoided.

Loop Diuretics + Metolazone⚠️Major

Concomitant use can cause unusually large or prolonged losses of fluid and electrolytes.

Loop Diuretics + Albuterol🟡Moderate

Non-potassium-sparing loop diuretics can cause ECG changes and hypokalemia that may be worsened by albuterol, especially at higher doses. Caution advised in co-administration.

Loop Diuretics + Albuterol Sulfate🟡Moderate

Non-potassium sparing diuretics can have ECG changes and hypokalemia acutely worsened by beta-agonists, especially at exceeded doses. Caution advised in co-administration.

Loop Diuretics + Arformoterol Tartrate🟡Moderate

Non-potassium sparing diuretics may cause ECG changes and hypokalemia that can be worsened by beta-agonists. Use with caution.

Loop Diuretics + Dichlorphenamide🟡Moderate

Increased risk of hypokalemia with coadministration of dichlorphenamide and loop diuretics.

Loop Diuretics + Diclofenac Sodium🟡Moderate

NSAIDs reduced the natriuretic effect of loop diuretics.

Loop Diuretics + Dopamine Hydrochloride🟡Moderate

Low-dose dopamine with diuretics may produce additive or potentiating effect on urine flow.

Loop Diuretics + Enalapril Maleate🟡Moderate

Enalapril attenuates potassium loss caused by thiazide diuretics; monitor serum potassium.

Loop Diuretics + Fluticasone Furoate And Vilanterol🟡Moderate

Electrocardiographic changes and hypokalemia may be worsened by vilanterol, especially at higher doses.

Loop Diuretics + Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate🟡Moderate

Non-potassium-sparing diuretics may cause hypokalemia and ECG changes that can be worsened by vilanterol, especially at higher doses.

Loop Diuretics + Formoterol Fumarate Dihydrate🟡Moderate

Non-potassium-sparing diuretics may cause hypokalemia and ECG changes that can worsen with concurrent beta-agonists. Use with caution.

Loop Diuretics + Ipratropium Bromide And Albuterol Sulfate🟡Moderate

Non-potassium sparing diuretics can worsen ECG changes and hypokalemia induced by β-agonists, especially at higher doses.

Loop Diuretics + Levalbuterol🟡Moderate

May worsen ECG changes or hypokalemia. Monitor potassium levels during coadministration.

Loop Diuretics + Levalbuterol Hydrochloride🟡Moderate

May worsen ECG changes or hypokalemia. Consider monitoring potassium levels during coadministration.

Loop Diuretics + Levalbuterol Inhalation Solution🟡Moderate

May worsen electrocardiographic changes and hypokalemia. Monitor potassium levels during coadministration.

Loop Diuretics + Salmeterol Xinafoate🟡Moderate

Non-potassium-sparing diuretics may have ECG changes and hypokalemia worsened by salmeterol, especially at higher doses.

Loop Diuretics + Sumatriptan Succinate And Naproxen Sodium🟡Moderate

NSAIDs can reduce natriuretic effect of loop diuretics. Monitor diuretic efficacy including antihypertensive effects.

Loop Diuretics + Terbutaline Sulfate🟡Moderate

Nonpotassium-sparing diuretics may cause ECG changes and hypokalemia that can be worsened by beta-agonists, especially at higher doses.

Loop Diuretics + Umeclidinium Bromide And Vilanterol Trifenatate🟡Moderate

May worsen electrocardiographic changes and/or hypokalemia associated with non-potassium-sparing diuretics when combined with beta-agonists. Use with caution.

Loop Diuretics + Zoledronic Acid🟡Moderate

Concomitant use with zoledronic acid may increase risk of hypocalcemia. Caution should be exercised when zoledronic acid is used in combination with loop diuretics.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.