Home›Hydrocodone Bitartrate And Acetaminophen

Hydrocodone Bitartrate And Acetaminophen

Also known as: Hydrocodone Bitartrate And Acetaminophen

Route: Oral

Check Hydrocodone Bitartrate And Acetaminophen Interactions →
32 interactions on record⛔ Black Box Warning

Hydrocodone Bitartrate And Acetaminophen has 32 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 26 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Alcohol, Nitrazepam, Anakinra. Patients taking Hydrocodone Bitartrate And Acetaminophen should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total
32
Contraindicated
2
Major
26
Moderate
3

Contraindicated (2)

Major (26)

Moderate (3)

Hydrocodone Bitartrate And Acetaminophen + Hydrocodoneℹ️Unknown

Drug Interactions Inhibitors of CYP3A4 and CYP2D6 The concomitant use of hydrocodone bitartrate and acetaminophen tablets and CYP3A4 inhibitors, such as macrolide antibiotics (e.g., erythromycin), azole-antifungal agents (e.g., ketoconazole), and protease inhibitors (e.g., ritonavir), can increase the plasma concentration of the hydrocodone from hydrocodone bitartrate and acetaminophen tablets, resulting in increased or prolonged opioid effects. These effects could be more pronounced with concomitant use of hydrocodone bitartrate and acetaminophen tablets and both CYP3A4 and CYP2D6 inhibitors, particularly when an inhibitor is added after a stable dose of hydrocodone bitartrate and acetaminophen tablets is achieved [see WARNINGS ]. After stopping a CYP3A4 inhibitor, as the effects of the inhibitor decline, the hydrocodone plasma concentration will decrease [see CLINICAL PHARMACOLOGY ], resulting in decreased opioid efficacy or a withdrawal syndrome in patients who had developed physical dependence to hydrocodone bitartrate and acetaminophen tablets.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.