Home›Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate

Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate

Also known as: Trelegy Ellipta

Route: Respiratory (Inhalation)

Check Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate Interactions →

5 interactions on record

Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate has 5 known drug interactions based on U.S. FDA drug labeling data. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Monoamine Oxidase Inhibitors (Maois), Nonselective Beta-Adrenergic Antagonists, Andthiazide. Patients taking Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 5
Major: 2
Moderate: 3

Major (2)

Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate + Monoamine Oxidase Inhibitors (Maois)— May potentiate effect of vilanterol on cardiovascular system. Use with extreme caution, especially within 2 weeks of dis…
Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate + Nonselective Beta-Adrenergic Antagonists— May block bronchodilatory effects of vilanterol and produce severe bronchospasm in COPD or asthma patients. Use with cau…

Moderate (3)

Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate + Andthiazide— Non-potassium-sparing diuretics may cause hypokalemia and ECG changes that can be worsened by vilanterol, especially at …
Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate + Ketoconazole— 7 DRUG INTERACTIONS • Strong cytochrome P450 3A4 inhibitors (e.g., ketoconazole): Use with caution. Concomitant administ…
Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate + Loop Diuretics— Non-potassium-sparing diuretics may cause hypokalemia and ECG changes that can be worsened by vilanterol, especially at …

Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate + Monoamine Oxidase Inhibitors (Maois)⚠️Major

May potentiate effect of vilanterol on cardiovascular system. Use with extreme caution, especially within 2 weeks of discontinuation.

Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate + Nonselective Beta-Adrenergic Antagonists⚠️Major

May block bronchodilatory effects of vilanterol and produce severe bronchospasm in COPD or asthma patients. Use with caution; cardioselective agents may be considered.

Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate + Andthiazide🟡Moderate

Non-potassium-sparing diuretics may cause hypokalemia and ECG changes that can be worsened by vilanterol, especially at higher doses.

Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate + Ketoconazole🟡Moderate

7 DRUG INTERACTIONS • Strong cytochrome P450 3A4 inhibitors (e.g., ketoconazole): Use with caution. Concomitant administration of the strong CYP3A4 inhibitor ketoconazole increases the systemic exposure to fluticasone furoate and vilanterol. Caution should be exercised when considering the coadministration of TRELEGY ELLIPTA with ketoconazole and other known strong CYP3A4 inhibitors [see Warnings and Precautions ( 5.9 ), Clinical Pharmacology ( 12.3 )] .

Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate + Loop Diuretics🟡Moderate

Non-potassium-sparing diuretics may cause hypokalemia and ECG changes that can be worsened by vilanterol, especially at higher doses.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.