Brand names: Percocet
5 interactions on record
Drug Interactions Inhibitors of CYP3A4 and CYP2D6 The concomitant use of oxycodone hydrochloride and acetaminophen oral solution and CYP3A4 inhibitors, such as macrolide antibiotics (e.g., erythromycin), azole-antifungal agents (e.g.
Source: FDA drug label - oxycodone hydrochloride and acetaminophen
ketoconazole), and protease inhibitors (e.g., ritonavir), can increase the plasma concentration of oxycodone, resulting in increased or prolonged opioid effects.
Source: FDA drug label - oxycodone hydrochloride and acetaminophen
Drug Interactions Inhibitors of CYP3A4 and CYP2D6 The concomitant use of oxycodone hydrochloride and acetaminophen oral solution and CYP3A4 inhibitors, such as macrolide antibiotics (e.g., erythromycin), azole-antifungal agents (e.g. ketoconazole), and protease inhibitors (e.g., ritonavir), can increase the plasma concentration of oxycodone, resulting in increased or prolonged opioid effects. These effects could be more pronounced with concomitant use of oxycodone hydrochloride and acetaminophen oral solution and CYP3A4 and CYP2D6 inhibitors, particularly when an inhibitor is added after a stable dose of oxycodone hydrochloride and acetaminophen oral solution is achieved [see WARNINGS ].
Source: FDA drug label - oxycodone hydrochloride and acetaminophen
Beta Blockers (Propranolol) Propranolol appears to inhibit the enzyme systems responsible for the glucuronidation and oxidation of acetaminophen.
Source: FDA drug label - oxycodone hydrochloride and acetaminophen
ketoconazole), and protease inhibitors (e.g., ritonavir), can increase the plasma concentration of oxycodone, resulting in increased or prolonged opioid effects.
Source: FDA drug label - oxycodone hydrochloride and acetaminophen