Empagliflozin, Metformin Hydrochloride has 23 known drug interactions based on U.S. FDA drug labeling data. 10 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Acetazolamide, Cimetidine, Dichlorphenamide. Patients taking Empagliflozin, Metformin Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 23
- Major
- 10
- Moderate
- 13
Major (10)
- Empagliflozin, Metformin Hydrochloride + Acetazolamide— Carbonic anhydrase inhibitor that decreases serum bicarbonate and may increase risk of lactic acidosis when used with SY…
- Empagliflozin, Metformin Hydrochloride + Cimetidine— OCT2/MATE inhibitor that may increase systemic metformin exposure and increase risk for lactic acidosis.
- Empagliflozin, Metformin Hydrochloride + Dichlorphenamide— Carbonic anhydrase inhibitor that decreases serum bicarbonate and may increase risk of lactic acidosis when used with SY…
- Empagliflozin, Metformin Hydrochloride + Dolutegravir— OCT2/MATE inhibitor that may increase systemic metformin exposure and increase risk for lactic acidosis.
- Empagliflozin, Metformin Hydrochloride + Insulin Human— Concomitant use increases hypoglycemia risk; lower insulin dosages may be required.
- Empagliflozin, Metformin Hydrochloride + Ranolazine— OCT2/MATE inhibitor that may increase systemic metformin exposure and increase risk for lactic acidosis.
- Empagliflozin, Metformin Hydrochloride + Sulfonylurea— Insulin secretagogue that increases hypoglycemia risk when combined; lower dosages may be required.
- Empagliflozin, Metformin Hydrochloride + Topiramate— Carbonic anhydrase inhibitor that decreases serum bicarbonate and may increase risk of lactic acidosis when used with SY…
- Empagliflozin, Metformin Hydrochloride + Vandetanib— OCT2/MATE inhibitor that may increase systemic metformin exposure and increase risk for lactic acidosis.
- Empagliflozin, Metformin Hydrochloride + Zonisamide— Carbonic anhydrase inhibitor that decreases serum bicarbonate and may increase risk of lactic acidosis when used with SY…
Moderate (13)
- Empagliflozin, Metformin Hydrochloride + Alcohol— Potentiates metformin's effect on lactate metabolism; excessive intake should be avoided.
- Empagliflozin, Metformin Hydrochloride + Calcium Channel Blockers— May produce hyperglycemia and lead to loss of glycemic control; monitor closely.
- Empagliflozin, Metformin Hydrochloride + Corticosteroids— May produce hyperglycemia and lead to loss of glycemic control; monitor closely.
- Empagliflozin, Metformin Hydrochloride + Diuretics— Coadministration with empagliflozin increases urine volume and voids, enhancing potential for volume depletion.
- Empagliflozin, Metformin Hydrochloride + Estrogens— May produce hyperglycemia and lead to loss of glycemic control; monitor closely.
- Empagliflozin, Metformin Hydrochloride + Isoniazid— May produce hyperglycemia and lead to loss of glycemic control; monitor closely.
- Empagliflozin, Metformin Hydrochloride + Lithium— SGLT2 inhibitor concomitant use with lithium may decrease lithium clearance.
- Empagliflozin, Metformin Hydrochloride + Niacin— May produce hyperglycemia and lead to loss of glycemic control; monitor closely.
- Empagliflozin, Metformin Hydrochloride + Oral Contraceptives— May produce hyperglycemia and lead to loss of glycemic control; monitor closely.
- Empagliflozin, Metformin Hydrochloride + Phenothiazines— May produce hyperglycemia and lead to loss of glycemic control; monitor closely.
- Empagliflozin, Metformin Hydrochloride + Phenytoin— May produce hyperglycemia and lead to loss of glycemic control; monitor closely.
- Empagliflozin, Metformin Hydrochloride + Thiazides— Diuretic that may produce hyperglycemia and lead to loss of glycemic control; monitor closely.
- Empagliflozin, Metformin Hydrochloride + Thyroid— May produce hyperglycemia and lead to loss of glycemic control; monitor closely.