Codeine has 7 known drug interactions based on U.S. FDA drug labeling data. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Alprazolam, Alprazolam C-Iv, Dextromethorphan Hydrobromide And Quinidine Sulfate. Patients taking Codeine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 7
- Major
- 4
- Moderate
- 1
- Minor
- 2
Major (4)
- Codeine + Alprazolam— Concomitant use increases risk of respiratory depression due to actions at different CNS receptor sites.
- Codeine + Alprazolam C-Iv— Concomitant use increases risk of respiratory depression due to additive CNS effects at different receptor sites. Monito…
- Codeine + Dextromethorphan Hydrobromide And Quinidine Sulfate— Quinidine-mediated inhibition of CYP2D6 may prevent conversion to active metabolite morphine, reducing analgesic/antitus…
- Codeine + Midazolam— Concomitant use increases risk of respiratory depression through actions at different CNS receptor sites.
Moderate (1)
- Codeine + Nabilone— Additive CNS depressant effects observed in clinical study. Caution must be used when administering nabilone in combinat…
Minor (2)
- Codeine + Terazosin— Terazosin has been used concomitantly with codeine in at least 50 patients with no interactions observed.
- Codeine + Terazosin Hydrochloride— Used concomitantly with terazosin in at least 50 patients with no interactions observed.