Exagamglogene Autotemcel has 5 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with G-Csf, Crizanlizumab, Hydroxyurea. Patients taking Exagamglogene Autotemcel should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 5
- Contraindicated
- 1
- Major
- 4
Contraindicated (1)
- Exagamglogene Autotemcel + G-Csf— G-CSF must not be used for CD34+ HSC mobilization in patients with SCD.
Major (4)
- Exagamglogene Autotemcel + Crizanlizumab— Discontinue at least 8 weeks prior to start of mobilization and conditioning due to unknown interaction potential with m…
- Exagamglogene Autotemcel + Hydroxyurea— Discontinue at least 8 weeks prior to start of mobilization and conditioning. No experience with use after CASGEVY infus…
- Exagamglogene Autotemcel + Iron Chelators— Discontinue at least 7 days prior to myeloablative conditioning. Avoid non-myelosuppressive iron chelators for 3 months …
- Exagamglogene Autotemcel + Voxelotor— Discontinue at least 8 weeks prior to start of mobilization and conditioning due to unknown interaction potential with m…