Bupivacaine Hydrochloride has 44 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 35 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Ergot-Type Oxytocic Drugs, Acetaminophen, Acetazolamide. Patients taking Bupivacaine Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 44
- Contraindicated
- 1
- Major
- 35
- Moderate
- 8
Contraindicated (1)
- Bupivacaine Hydrochloride + Ergot-Type Oxytocic Drugs— Concurrent administration with bupivacaine and epinephrine may cause severe, persistent hypertension or cerebrovascular …
Major (35)
- Bupivacaine Hydrochloride + Acetaminophen— Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.
- Bupivacaine Hydrochloride + Acetazolamide— Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.
- Bupivacaine Hydrochloride + Articaine— Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.
- Bupivacaine Hydrochloride + Benzocaine— Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.
- Bupivacaine Hydrochloride + Chloroquine— Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.
- Bupivacaine Hydrochloride + Cyclophosphamide— Examples of Drugs Associated with Methemoglobinemia: Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitro…
- Bupivacaine Hydrochloride + Dapsone— Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.
- Bupivacaine Hydrochloride + Epinephrine— Serious dose-related cardiac arrhythmias may occur if preparations containing vasoconstrictor are used during or after p…
- Bupivacaine Hydrochloride + Flutamide— Examples of Drugs Associated with Methemoglobinemia: Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitro…
- Bupivacaine Hydrochloride + Hydroxyurea— Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.
- Bupivacaine Hydrochloride + Ifosfamide— Examples of Drugs Associated with Methemoglobinemia: Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitro…
- Bupivacaine Hydrochloride + Lidocaine— Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.
- Bupivacaine Hydrochloride + Mepivacaine— Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.
- Bupivacaine Hydrochloride + Metoclopramide— Examples of Drugs Associated with Methemoglobinemia: Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitro…
- Bupivacaine Hydrochloride + Monoamine Oxidase Inhibitors (Maois)— Administration may produce severe, prolonged hypertension. Concurrent use should generally be avoided.
- Bupivacaine Hydrochloride + Nitric Oxide— Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.
- Bupivacaine Hydrochloride + Nitrofurantoin— Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.
- Bupivacaine Hydrochloride + Nitroglycerin— Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.
- Bupivacaine Hydrochloride + Nitroprusside— Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.
- Bupivacaine Hydrochloride + Nitrous Oxide— Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.
- Bupivacaine Hydrochloride + Nonselective Beta-Adrenergic Antagonists— May cause severe hypertension and bradycardia. Concurrent use should generally be avoided.
- Bupivacaine Hydrochloride + Para-Aminosalicylic Acid— Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.
- Bupivacaine Hydrochloride + Phenobarbital— Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.
- Bupivacaine Hydrochloride + Phenytoin— Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.
- Bupivacaine Hydrochloride + Prilocaine— Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.
- Bupivacaine Hydrochloride + Primaquine— Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.
- Bupivacaine Hydrochloride + Procaine— Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.
- Bupivacaine Hydrochloride + Quinine— Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.
- Bupivacaine Hydrochloride + Rasburicase— Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.
- Bupivacaine Hydrochloride + Ropivacaine— Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.
- Bupivacaine Hydrochloride + Sulfasalazine— Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.
- Bupivacaine Hydrochloride + Tetracaine— Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.
- Bupivacaine Hydrochloride + Topical Local Anesthetics— Serious dose-related cardiac arrhythmias may occur if preparations containing vasoconstrictor are used during or after a…
- Bupivacaine Hydrochloride + Valproate Sodium— Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.
- Bupivacaine Hydrochloride + Vasopressin— Concurrent administration may cause severe, persistent hypertension or cerebrovascular accidents.
Moderate (8)
- Bupivacaine Hydrochloride + Acidifying Agents— Increased risk of methemoglobinemia when concurrently exposed to antineoplastic agents.
- Bupivacaine Hydrochloride + Butyrophenones— May reduce or reverse the pressor effect of epinephrine in local anesthetic solutions.
- Bupivacaine Hydrochloride + Local Anesthetics (Articaine, Benzocaine, Lidocaine, Mepivacaine, Prilocaine, Procaine, Ropivacaine, Tetracaine)— Toxic effects of local anesthetics are additive. Monitor patients for neurologic and cardiovascular effects related to l…
- Bupivacaine Hydrochloride + Macrolide Antibiotics— Increased risk of methemoglobinemia when concurrently exposed to antibiotics.
- Bupivacaine Hydrochloride + Nitrates— Increased risk of methemoglobinemia when concurrently exposed to nitrates.
- Bupivacaine Hydrochloride + Nitrites— Increased risk of methemoglobinemia when concurrently exposed to nitrites.
- Bupivacaine Hydrochloride + Oral Anticoagulants— Increased risk of methemoglobinemia when concurrently exposed to anticonvulsants.
- Bupivacaine Hydrochloride + Phenothiazines— May reduce or reverse the pressor effect of epinephrine in local anesthetic solutions.