Resmetirom has 6 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 5 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Gemfibrozil, Atorvastatin, Clopidogrel. Patients taking Resmetirom should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 6
- Contraindicated
- 1
- Major
- 5
Contraindicated (1)
- Resmetirom + Gemfibrozil— Strong CYP2C8 inhibitor; concomitant use not recommended as it increases resmetirom Cmax and AUC, increasing risk of adv…
Major (5)
- Resmetirom + Atorvastatin— REZDIFFRA increases plasma concentrations of atorvastatin; limit daily dosage to 40 mg to reduce risk of statin-related …
- Resmetirom + Clopidogrel— Moderate CYP2C8 inhibitor; reduce REZDIFFRA dosage as it increases resmetirom Cmax and AUC, increasing risk of adverse r…
- Resmetirom + Pravastatin— REZDIFFRA increases plasma concentrations of pravastatin; limit daily dosage to 40 mg to reduce risk of statin-related a…
- Resmetirom + Rosuvastatin— REZDIFFRA increases plasma concentrations of rosuvastatin; limit daily dosage to 20 mg to reduce risk of statin-related …
- Resmetirom + Simvastatin— REZDIFFRA increases plasma concentrations of simvastatin; limit daily dosage to 20 mg to reduce risk of statin-related a…