Colestipol has 31 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Chenodiol, Hydrochlorothiazide, Levothyroxine And Liothyronine. Patients taking Colestipol should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 31
- Contraindicated
- 1
- Major
- 2
- Moderate
- 28
Contraindicated (1)
- Colestipol + Chenodiol— Bile acid sequestering agent that decreases absorption of CHENODIOL in the intestine, resulting in decreased efficacy. C…
Major (2)
- Colestipol + Hydrochlorothiazide— Absorption of hydrochlorothiazide is impaired; single doses reduce absorption by up to 43%.
- Colestipol + Levothyroxine And Liothyronine— Colestipol binds thyroid hormones in the intestine, impairing their absorption. Space administration by 4-5 hours.
Moderate (28)
- Colestipol + Alendronate Sodium And Cholecalciferol— Bile acid sequestrant that may impair the absorption of cholecalciferol. Additional vitamin D supplementation should be …
- Colestipol + Amiloride Hydrochloride And Hydrochlorothiazide— Absorption of hydrochlorothiazide is impaired; single doses bind hydrochlorothiazide and reduce its absorption by up to …
- Colestipol + Candesartan Cilexetil And Hydrochlorothiazide— Binds hydrochlorothiazide and reduces its absorption by up to 43%. Stagger dosing appropriately.
- Colestipol + Chlorothiazide— Colestipol resin may bind thiazide diuretics and reduce diuretic absorption from the gastrointestinal tract.
- Colestipol + Cholic Acid— Bile acid binding resin that adsorbs and reduces bile acid absorption, potentially reducing CHOLBAM efficacy. Take CHOLB…
- Colestipol + Digoxin— Decreases digoxin concentrations. Requires monitoring and dose adjustment.
- Colestipol + Folic Acid— Colestipol impairs gastrointestinal folate uptake through binding of dietary folate.
- Colestipol + Irbesartan And Hydrochlorothiazide— Reduced absorption of thiazides when coadministered with colestipol.
- Colestipol + Levothyroxine Sodium— Bile acid sequestrant known to decrease levothyroxine absorption, potentially resulting in hypothyroidism.
- Colestipol + Liothyronine Sodium— Bile acid sequestrant that may decrease T3 absorption by binding and delaying or preventing absorption, potentially resu…
- Colestipol + Losartan Potassium And Hydrochlorothiazide— Reduced absorption of thiazides. Monitor therapeutic effect of hydrochlorothiazide.
- Colestipol + Maralixibat Chloride— Bile acid binding resin may bind to maralixibat in the gut. Administer LIVMARLI at least 4 hours before or after colesti…
- Colestipol + Metoprolol Tartrate And Hydrochlorothiazide— Ion exchange resin that reduces hydrochlorothiazide absorption by 43%. Stagger dosing with 4-6 hours separation.
- Colestipol + Odevixibat— Bile acid binding resins may bind odevixibat in the gut, reducing BYLVAY efficacy. Administer at least 4 hours before or…
- Colestipol + Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide— Reduces absorption of hydrochlorothiazide, decreasing its therapeutic effect.
- Colestipol + Olmesartan Medoxomil And Amlodipine Besylate And Hydrochlorothiazide— Reduces absorption of hydrochlorothiazide.
- Colestipol + Olmesartan Medoxomil And Hydrochlorothiazide— Reduces absorption of thiazides.
- Colestipol + Olmesartan Medoxomil-Hydrochlorothiazide— Reduces absorption of thiazides. Monitor for reduced diuretic efficacy.
- Colestipol + Pravastatin Sodium— Concomitant administration may decrease pravastatin bioavailability; timing separation recommended.
- Colestipol + Prenatal Multivitamin Tablet And Combination Omega-3 Softgel/Mineral Capsule— Reduces folic acid absorption and reduces serum folate levels.
- Colestipol + Propranolol Hydrochloride— Co-administered colestipol significantly reduces propranolol plasma concentrations, resulting in loss of efficacy.
- Colestipol + Telmisartan And Hydrochlorothiazide— Colestipol reduces absorption of thiazides, potentially decreasing their efficacy.
- Colestipol + Thyroid— Colestipol binds levothyroxine and liothyronine in the intestine, impairing absorption. Four to five hours should elapse…
- Colestipol + Thyroid, Porcine— Binds levothyroxine (T4) and liothyronine (T3) in the intestine, impairing absorption of thyroid hormones. Separate admi…
- Colestipol + Ursodiol— Bile acid sequestering agent that may interfere with ursodiol action by reducing its absorption.
- Colestipol + Ursosiol— Bile acid sequestering agent may interfere with ursodiol absorption and reduce its effectiveness.
- Colestipol + Usodiol— Bile acid sequestering agent that may interfere with ursodiol action by reducing its absorption.
- Colestipol + Valsartan And Hydrochlorothiazide— Ion exchange resin may interact with hydrochlorothiazide; dosage staggering is recommended.