Aspirin (High-Dose) has 8 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Dichlorphenamide, Dorzolamide, Dorzolamide Hydrochloride. Patients taking Aspirin (High-Dose) should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 8
- Contraindicated
- 1
- Major
- 4
- Moderate
- 3
Contraindicated (1)
- Aspirin (High-Dose) + Dichlorphenamide— High-dose aspirin with dichlorphenamide causes anorexia, tachypnea, lethargy, and coma. Concomitant use is contraindicat…
Major (4)
- Aspirin (High-Dose) + Dorzolamide— Potential for acid-base and electrolyte disturbances and toxicity when dorzolamide is used with high-dose salicylate the…
- Aspirin (High-Dose) + Dorzolamide Hydrochloride— Potential for acid-base and electrolyte disturbances that may result in salicylate toxicity, as reported with oral carbo…
- Aspirin (High-Dose) + Dorzolamide Hydrochloride And Timolol Maleate Preservative Free— Potential for acid-base and electrolyte disturbances that may result in salicylate toxicity, as reported with oral carbo…
- Aspirin (High-Dose) + Methazolamide— Concomitant use may cause anorexia, tachypnea, lethargy, coma, and death; caution advised with high-dose aspirin.
Moderate (3)
- Aspirin (High-Dose) + Brinzolamide— Rare instances of acid-base and electrolyte alterations have occurred with high-dose salicylate therapy in patients rece…
- Aspirin (High-Dose) + Brinzolamide/Brimonidine Tartrate— May produce acid-base and electrolyte alterations. Rare instances reported with oral carbonic anhydrase inhibitors combi…
- Aspirin (High-Dose) + Dorzolamide Hydrochloride Ophthalmic— Potential for acid-base and electrolyte disturbances and drug toxicity with high-dose salicylate therapy.