Seladelpar Lysine has 6 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. Notable interactions include combinations with Probenecid, Bile Acid Binding Resins, Cyclosporine. Patients taking Seladelpar Lysine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 6
- Contraindicated
- 1
- Moderate
- 5
Contraindicated (1)
- Seladelpar Lysine + Probenecid— Probenecid increases seladelpar exposure. Avoid concomitant administration.
Moderate (5)
- Seladelpar Lysine + Bile Acid Binding Resins— Bile acid sequestrants decrease seladelpar absorption and systemic exposure, potentially reducing efficacy. Administer a…
- Seladelpar Lysine + Cyclosporine— Cyclosporine (dual/multiple inhibitor of OATP1B1, OATP1B3, BCRP) increases seladelpar exposure. Monitor for adverse effe…
- Seladelpar Lysine + Fluconazole— Dual Moderate CYP2C9 and Moderate or Strong CYP3A4 Inhibitors (e.g., fluconazole) ↑ seladelpar Monitor patients for adve…
- Seladelpar Lysine + Mao Inhibitors— Strong CYP2C9 inhibitors increase seladelpar exposure. Monitor patients for adverse effects during concomitant use.
- Seladelpar Lysine + Rifampin— Rifampin decreases seladelpar exposure and may result in delayed or suboptimal biochemical response. Monitor biochemical…