Suzetrigine has 5 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Mao Inhibitors, Cyp3a Inducers, Grapefruit Products. Patients taking Suzetrigine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 5
- Contraindicated
- 1
- Major
- 2
- Moderate
- 2
Contraindicated (1)
- Suzetrigine + Mao Inhibitors— Concomitant use of JOURNAVX with strong CYP3A inhibitors is contraindicated. Strong CYP3A inhibitors increase suzetrigin…
Major (2)
- Suzetrigine + Cyp3a Inducers— Avoid JOURNAVX use with strong CYP3A inducers. Concomitant use results in reduced exposures of suzetrigine and M6-SUZ, w…
- Suzetrigine + Grapefruit Products— Food or drink containing grapefruit should be avoided during treatment with JOURNAVX. Grapefruit inhibits CYP3A, increas…
Moderate (2)
- Suzetrigine + Estrogen-Containing Oral Contraceptive Preparations (Ethinylestradiol And Levonorgestrel)— Patients using hormonal contraceptives with progestins other than levonorgestrel and norethindrone should use additional…
- Suzetrigine + Sensitive Cyp3a Substrates— Dosage modification of sensitive CYP3A substrates may be required when initiating or discontinuing JOURNAVX. JOURNAVX is…