Colistimethate has 7 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 6 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Sodium Cephalothin, Gallamine, Other Anticholinergic Agents. Patients taking Colistimethate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 7
- Contraindicated
- 1
- Major
- 6
Contraindicated (1)
- Colistimethate + Sodium Cephalothin— May enhance nephrotoxicity of colistimethate; concomitant use should be avoided.
Major (6)
- Colistimethate + Gallamine— Potentiates neuromuscular blocking effect and should be used with extreme caution in patients being treated with colisti…
- Colistimethate + Other Anticholinergic Agents— Potentiates neuromuscular blocking effect and should be used with extreme caution in patients being treated with colisti…
- Colistimethate + Polymyxins— Polymyxin interferes with nerve transmission at the neuromuscular junction and should not be given concomitantly except …
- Colistimethate + Sodium Citrate— Potentiates neuromuscular blocking effect and should be used with extreme caution in patients being treated with colisti…
- Colistimethate + Succinylcholine— Potentiates neuromuscular blocking effect and should be used with extreme caution in patients being treated with colisti…
- Colistimethate + Tubocurarine— Curariform muscle relaxant that potentiates neuromuscular blocking effect; use with extreme caution in patients treated …