Hydrocortisone Acetate has 18 known drug interactions based on U.S. FDA drug labeling data. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Amphotericin B, Anticholinesterase Agents, Cyclosporine. Patients taking Hydrocortisone Acetate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 18
- Major
- 4
- Moderate
- 14
Major (4)
- Hydrocortisone Acetate + Amphotericin B— Concomitant use may cause hypokalemia and has been associated with cardiac enlargement and congestive heart failure.
- Hydrocortisone Acetate + Anticholinesterase Agents— Concomitant use may produce severe weakness in patients with myasthenia gravis.
- Hydrocortisone Acetate + Cyclosporine— Increased activity of both cyclosporine and corticosteroids may occur; convulsions have been reported.
- Hydrocortisone Acetate + Ketoconazole— Ketoconazole decreases corticosteroid metabolism by up to 60%, increasing risk of corticosteroid side effects.
Moderate (14)
- Hydrocortisone Acetate + Acetylsalicylic Acid— Concomitant use increases risk of gastrointestinal side effects and requires caution in hypoprothrombinemia.
- Hydrocortisone Acetate + Acidifying Agents— Corticosteroids may increase blood glucose, requiring dosage adjustments of antidiabetic agents.
- Hydrocortisone Acetate + Aminoglutethimide— Aminoglutethimide may lead to loss of corticosteroid-induced adrenal suppression.
- Hydrocortisone Acetate + Barbiturates— Barbiturates induce hepatic enzyme activity, enhancing corticosteroid metabolism and may require dosage increase.
- Hydrocortisone Acetate + Carbamazepine— Carbamazepine induces hepatic enzyme activity, enhancing corticosteroid metabolism and may require dosage increase.
- Hydrocortisone Acetate + Cholestyramine Light— Cholestyramine may increase the clearance of corticosteroids, reducing corticosteroid effects.
- Hydrocortisone Acetate + Digitalis Glycosides— Patients may be at increased risk of arrhythmias due to hypokalemia from corticosteroid use.
- Hydrocortisone Acetate + Estrogens— Estrogens may decrease hepatic metabolism of corticosteroids, increasing their effect.
- Hydrocortisone Acetate + Isoniazid— Serum concentrations of isoniazid may be decreased by corticosteroids.
- Hydrocortisone Acetate + Macrolide Antibiotics— Macrolide antibiotics significantly decrease corticosteroid clearance, increasing corticosteroid levels.
- Hydrocortisone Acetate + Oral Contraceptives— Oral contraceptives may decrease hepatic metabolism of corticosteroids, increasing their effect.
- Hydrocortisone Acetate + Phenytoin— Phenytoin induces hepatic enzyme activity, enhancing corticosteroid metabolism and may require dosage increase.
- Hydrocortisone Acetate + Rifampin— Rifampin induces hepatic enzyme activity, enhancing corticosteroid metabolism and may require dosage increase.
- Hydrocortisone Acetate + Warfarin— Corticosteroids inhibit warfarin response; coagulation indices should be monitored.