Imatinib Mesylate has 8 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Warfarin, Imatinib, Methotrexate. Patients taking Imatinib Mesylate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 8
- Contraindicated
- 1
- Major
- 2
- Moderate
- 5
Contraindicated (1)
- Imatinib Mesylate + Warfarin— Warfarin should not be used in patients requiring anticoagulation; use low-molecular weight or standard heparin instead …
Major (2)
- Imatinib Mesylate + Imatinib— ( 7.5 ) 7.1 Agents Inducing CYP3A Metabolism Concomitant administration of Gleevec and strong CYP3A4 inducers may reduce…
- Imatinib Mesylate + Methotrexate— Imatinib mesylate delays clearance of methotrexate and results in sustained methotrexate concentrations when used at hig…
Moderate (5)
- Imatinib Mesylate + Calcium Channel Blockers— Imatinib increases plasma concentration of CYP3A4 metabolized dihydropyridine calcium channel blockers. Use caution with…
- Imatinib Mesylate + Cyp3a Inducers— Strong CYP3A4 inducers may decrease imatinib mesylate Cmax and AUC; consider alternative agents.
- Imatinib Mesylate + Grapefruit Juice— Grapefruit juice may increase plasma concentrations of imatinib; avoid grapefruit juice.
- Imatinib Mesylate + Mao Inhibitors— Imatinib increases plasma concentration of certain CYP3A4 metabolized HMG-CoA reductase inhibitors. Use caution with dru…
- Imatinib Mesylate + Triazolam— Imatinib increases plasma concentration of CYP3A4 metabolized triazolo-benzodiazepines. Use caution with drugs that have…