Lofexidine has 6 known drug interactions based on U.S. FDA drug labeling data. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Methadone, Alcohol, Barbiturates. Patients taking Lofexidine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 6
- Major
- 1
- Moderate
- 5
Major (1)
- Lofexidine + Methadone— Both drugs prolong QT interval. ECG monitoring is recommended when used concomitantly.
Moderate (5)
- Lofexidine + Alcohol— Lofexidine may potentiate CNS depressant effects of alcohol.
- Lofexidine + Barbiturates— Lofexidine may potentiate CNS depressant effects of barbiturates.
- Lofexidine + Naltrexone— Coadministration may reduce efficacy of oral naltrexone if taken within 2 hours of lofexidine due to altered pharmacokin…
- Lofexidine + Nitrazepam— Lofexidine potentiates CNS depressant effects of benzodiazepines.
- Lofexidine + Paroxetine— CYP2D6 inhibitor that increases lofexidine plasma levels by 28%. Monitor for orthostatic hypotension and bradycardia.