Loratadine

3 interactions on record

Loratadine has 3 known drug interactions based on U.S. FDA drug labeling data. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Amiodarone Hydrochloride, Carbamazepine, Dermatophagoides Farinae. Patients taking Loratadine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 3
Major: 1
Moderate: 2

Major (1)

Loratadine + Amiodarone Hydrochloride— Non-sedating antihistamine metabolized by CYP3A. QT interval prolongation and torsades de pointes reported with coadmini…

Moderate (2)

Loratadine + Carbamazepine— CYP3A4 inhibitor that increases carbamazepine plasma levels; close monitoring and dosage adjustment may be required.
Loratadine + Dermatophagoides Farinae— Second-generation antihistamine that suppresses histamine skin test reactions and could mask positive response. Avoid sk…

Loratadine + Amiodarone Hydrochloride⚠️Major

Non-sedating antihistamine metabolized by CYP3A. QT interval prolongation and torsades de pointes reported with coadministration.

Loratadine + Carbamazepine🟡Moderate

CYP3A4 inhibitor that increases carbamazepine plasma levels; close monitoring and dosage adjustment may be required.

Loratadine + Dermatophagoides Farinae🟡Moderate

Second-generation antihistamine that suppresses histamine skin test reactions and could mask positive response. Avoid skin testing within 3-10 days of use.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.