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Cosyntropin

Also known as: Cortrosyn

Adrenocorticotropic Hormone

Route: Intramuscular, Intravenous

3 interactions on record

Cosyntropin has 3 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Diuretics, Estrogens, Spironolactone. Patients taking Cosyntropin should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 3
Moderate: 3

Moderate (3)

Cosyntropin + Diuretics— Corticotropin may accentuate the electrolyte loss associated with diuretic therapy.
Cosyntropin + Estrogens— May elevate plasma total cortisol levels and affect test accuracy. Stop estrogen-containing drugs 4-6 weeks before COSYN…
Cosyntropin + Spironolactone— May falsely elevate plasma cortisol levels, affecting test accuracy. Should be stopped on day of COSYNTROPIN testing.

Cosyntropin + Diuretics🟡Moderate

Corticotropin may accentuate the electrolyte loss associated with diuretic therapy.

Cosyntropin + Estrogens🟡Moderate

May elevate plasma total cortisol levels and affect test accuracy. Stop estrogen-containing drugs 4-6 weeks before COSYNTROPIN testing to allow cortisol binding globulin normalization.

Cosyntropin + Spironolactone🟡Moderate

May falsely elevate plasma cortisol levels, affecting test accuracy. Should be stopped on day of COSYNTROPIN testing.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.