Megestrol Acetate has 4 known drug interactions based on U.S. FDA drug labeling data. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Indinavir, Warfarin. Patients taking Megestrol Acetate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 4
- Major
- 1
- Moderate
- 1
- Minor
- 2
Major (1)
- Megestrol Acetate + Indinavir— Megestrol acetate significantly decreases indinavir exposure; higher doses of indinavir should be considered when coadmi…
Moderate (1)
- Megestrol Acetate + Warfarin— Megestrol acetate may interact with warfarin and increase International Normalized Ratio (INR). Closely monitor INR in p…
Minor (2)
- Megestrol Acetate + Rifabutin— No significant alterations in pharmacokinetic parameters of rifabutin when megestrol acetate is administered with it, th…
- Megestrol Acetate + Zidovudine— No significant alterations in pharmacokinetic parameters of zidovudine when megestrol acetate is administered with it, t…