Adenosine has 14 known drug interactions based on U.S. FDA drug labeling data. 5 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Aspirin And Extended - Release Dipyridamole, Asprin And Extended-Release Dipyridamole, Digoxin. Patients taking Adenosine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 14
- Major
- 5
- Moderate
- 9
Major (5)
- Adenosine + Aspirin And Extended - Release Dipyridamole— Dipyridamole increases plasma levels and cardiovascular effects of adenosine. Adjustment of adenosine dosage may be nece…
- Adenosine + Asprin And Extended-Release Dipyridamole— Dipyridamole increases plasma levels and cardiovascular effects of adenosine. Adjustment of adenosine dosage may be nece…
- Adenosine + Digoxin— Rarely associated with ventricular fibrillation when combined with adenosine injection. Use with caution due to potentia…
- Adenosine + Dipyridamole— Dipyridamole increases plasma levels and cardiovascular effects of adenosine. Adjustment of adenosine dosage may be nece…
- Adenosine + Verapamil— Rarely associated with ventricular fibrillation when combined with adenosine injection. Use with caution due to potentia…
Moderate (9)
- Adenosine + Aminophylline— Theophylline blocks adenosine receptors, requiring higher doses of adenosine to achieve therapeutic effect.
- Adenosine + Aspirin And Dipyridamole— Dipyridamole increases plasma levels and cardiovascular effects of adenosine. Adjustment of adenosine dosage may be nece…
- Adenosine + Caffeine— Antagonizes the effects of adenosine, potentially reducing efficacy. Larger doses of adenosine may be required.
- Adenosine + Calcium Channel Blockers— Given with adenosine without apparent adverse interactions, but adenosine should be used with caution due to potential a…
- Adenosine + Carbamazepine— Increases the degree of heart block produced by adenosine, potentially resulting in higher degrees of AV node block.
- Adenosine + Cardiac Glycosides— Given with adenosine without apparent adverse interactions, but adenosine should be used with caution due to potential a…
- Adenosine + Nonselective Beta-Adrenergic Antagonists— Given with adenosine without apparent adverse interactions, but adenosine should be used with caution due to potential a…
- Adenosine + Theophylline— Theophylline blocks adenosine receptors, potentially reducing adenosine's therapeutic effects.
- Adenosine + Theophylline Anhydrous— Theophylline blocks adenosine receptors, requiring higher doses of adenosine to achieve therapeutic effect.