Miglitol has 10 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Charcoal, Propranolol, Ranitidine. Patients taking Miglitol should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 10
- Contraindicated
- 1
- Major
- 2
- Moderate
- 4
- Minor
- 3
Contraindicated (1)
- Miglitol + Charcoal— Intestinal adsorbents like charcoal may reduce the effect of miglitol and should not be taken concomitantly.
Major (2)
- Miglitol + Propranolol— Miglitol significantly reduced propranolol bioavailability by approximately 40% in healthy volunteer studies.
- Miglitol + Ranitidine— Miglitol significantly reduced ranitidine bioavailability by approximately 60% in healthy volunteer studies.
Moderate (4)
- Miglitol + Digoxin— Decreases digoxin concentrations. Requires monitoring and dose adjustment.
- Miglitol + Glibenclamide— Co-administration of miglitol with glyburide resulted in 8-25% lower glyburide AUC and Cmax values across multiple studi…
- Miglitol + Pancreatin— Digestive enzyme preparations containing carbohydrate-splitting enzyme pancreatin may reduce the effect of miglitol and …
- Miglitol + Pancrelipase— Digestive enzyme preparations containing carbohydrate-splitting enzyme amylase may reduce the effect of miglitol and sho…
Minor (3)
- Miglitol + Metformin— Miglitol reduced mean AUC and Cmax values for metformin by 12-13%, but this difference was not statistically significant…
- Miglitol + Nifedipine— No effect of miglitol was observed on the pharmacokinetics or pharmacodynamics of nifedipine.
- Miglitol + Warfarin— No effect of miglitol was observed on the pharmacokinetics or pharmacodynamics of warfarin.