Cytarabine has 5 known drug interactions based on U.S. FDA drug labeling data. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Cyclophosphamide, Cyclophosphamide Injection, Solution, Flucytosine. Patients taking Cytarabine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 5
- Major
- 3
- Moderate
- 2
Major (3)
- Cytarabine + Cyclophosphamide— Increased cardiotoxicity may result from combined effect with cyclophosphamide.
- Cytarabine + Cyclophosphamide Injection, Solution— Cytarabine potentiates cyclophosphamide's cardiotoxicity when used concomitantly or sequentially.
- Cytarabine + Flucytosine— Cytosine arabinoside inactivates the antifungal activity of flucytosine through competitive inhibition.
Moderate (2)
- Cytarabine + Beta-Acetyldigoxin— Cytarabine may decrease steady-state plasma beta-acetyldigoxin concentrations and renal glycoside excretion. Monitoring …
- Cytarabine + Gentamicin— In vitro study showed cytarabine-related antagonism of gentamicin susceptibility against K. pneumoniae. Lack of prompt t…