Calcitriol Capsules 0.25 Mcg has 11 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Vitamin D, Antacids Containing Magnesium, Digitalis Glycosides. Patients taking Calcitriol Capsules 0.25 Mcg should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 11
- Contraindicated
- 1
- Major
- 2
- Moderate
- 8
Contraindicated (1)
- Calcitriol Capsules 0.25 Mcg + Vitamin D— Pharmacological doses of vitamin D and derivatives should be withheld during calcitriol treatment to avoid additive effe…
Major (2)
- Calcitriol Capsules 0.25 Mcg + Antacids Containing Magnesium— Magnesium-containing preparations (e.g., antacids) should not be taken during calcitriol therapy in chronic renal dialys…
- Calcitriol Capsules 0.25 Mcg + Digitalis Glycosides— Hypercalcemia resulting from calcitriol use may precipitate cardiac arrhythmias in digitalis-treated patients; dosage mu…
Moderate (8)
- Calcitriol Capsules 0.25 Mcg + Calcium Antagonists— Uncontrolled intake of additional calcium-containing preparations should be avoided during calcitriol therapy.
- Calcitriol Capsules 0.25 Mcg + Cholestyramine Light— May reduce intestinal absorption of calcitriol by impairing fat-soluble vitamin absorption.
- Calcitriol Capsules 0.25 Mcg + Corticosteroids— Functional antagonism exists; corticosteroids inhibit calcium absorption while calcitriol promotes it. Concurrent use re…
- Calcitriol Capsules 0.25 Mcg + Ketoconazole— Ketoconazole may inhibit synthetic and catabolic enzymes of calcitriol, potentially reducing serum calcitriol concentrat…
- Calcitriol Capsules 0.25 Mcg + Phenobarbital— May reduce endogenous plasma levels of 25(OH)D3 and calcitriol; higher calcitriol doses may be necessary.
- Calcitriol Capsules 0.25 Mcg + Phenytoin— May reduce endogenous plasma levels of 25(OH)D3 and calcitriol; higher calcitriol doses may be necessary.
- Calcitriol Capsules 0.25 Mcg + Phosphate-Binding Agents— Dosage of phosphate-binding agents must be adjusted based on serum phosphate concentration due to calcitriol's effect on…
- Calcitriol Capsules 0.25 Mcg + Thiazides— Concomitant use may cause hypercalcemia; precaution should be taken when coadministration is necessary.