Danazol has 28 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 6 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Ezetimibe And Simvastatin, Simvastatin, Atorvastatin. Patients taking Danazol should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 28
- Contraindicated
- 2
- Major
- 6
- Moderate
- 19
Contraindicated (2)
- Danazol + Ezetimibe And Simvastatin— Contraindicated due to increased risk of myopathy and rhabdomyolysis with ezetimibe and simvastatin tablets.
- Danazol + Simvastatin— Increases risk of myopathy and rhabdomyolysis when used with simvastatin. Concomitant use is contraindicated.
Major (6)
- Danazol + Atorvastatin— Concomitant use increases risk of myopathy and rhabdomyolysis. Caution should be exercised and dose restrictions may app…
- Danazol + Cyclosporine— Danazol raises plasma levels of cyclosporin, leading to increased renal toxicity. Monitoring and dose adjustments may be…
- Danazol + Insulin Glargine— May decrease blood glucose lowering effect of LANTUS. Dosage increases and increased glucose monitoring may be required.
- Danazol + Lovastatin— Increases risk of myopathy/rhabdomyolysis, particularly with higher doses of lovastatin.
- Danazol + Tacrolimus— Danazol raises plasma levels of tacrolimus, leading to increased renal toxicity. Monitoring and dose adjustments may be …
- Danazol + Warfarin— Danazol prolongs prothrombin time in patients stabilized on warfarin, increasing anticoagulant effect.
Moderate (19)
- Danazol + Carbamazepine— CYP3A4 inhibitor that increases carbamazepine plasma levels. Close monitoring of carbamazepine levels and dosage adjustm…
- Danazol + Glimepiride— May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.
- Danazol + Glipizide— May reduce glucose-lowering effect of glipizide, leading to worsening glycemic control; monitor closely.
- Danazol + Insulin Aspart Injection— May decrease the blood glucose lowering effect. Dose adjustment and increased glucose monitoring required.
- Danazol + Insulin Aspart-Szjj— May decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.
- Danazol + Insulin Degludec— May decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.
- Danazol + Insulin Degludec And Liraglutide— May decrease blood glucose-lowering effect; dosage increases and increased glucose monitoring may be required.
- Danazol + Insulin Detemir— May decrease blood glucose lowering effect of insulin detemir. Dosage increases and increased glucose monitoring may be …
- Danazol + Insulin Glargine And Lixisenatide— May decrease the blood glucose lowering effect. Dose increases and increased glucose monitoring may be required.
- Danazol + Insulin Glargine-Aglr— May decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.
- Danazol + Insulin Glargine-Yfgn— May decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.
- Danazol + Insulin Glulisine— May decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.
- Danazol + Insulin Human— May decrease blood glucose lowering effect; dose adjustment and increased glucose monitoring may be required.
- Danazol + Insulin Icodec-Abae— May decrease blood glucose lowering effect of Awiqli. Dose increases and increased glucose monitoring may be required.
- Danazol + Insulin Lispro— May decrease blood glucose lowering effect; dose adjustment and increased glucose monitoring required.
- Danazol + Insulin Lispro-Aabc— May decrease blood glucose lowering effect. Dose increases and increased glucose monitoring may be required.
- Danazol + Rapamycin— Weak/moderate CYP3A4/P-gp inhibitor that may increase sirolimus concentrations. Monitor and adjust dosage as needed.
- Danazol + Repaglinide— May decrease blood glucose lowering effect of repaglinide. Dose increases and increased glucose monitoring may be requir…
- Danazol + Vitamin D— Danazol can increase the calcemic response to synthetic vitamin D analogs in primary hypoparathyroidism.