Cns Depressants has 24 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 10 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Metoclopramide Hydrochloride, Butalbital, Acetaminophen And Caffeine, Butalbital, Aspirin, And Caffeine. Patients taking Cns Depressants should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 24
- Contraindicated
- 1
- Major
- 10
- Moderate
- 13
Contraindicated (1)
- Cns Depressants + Metoclopramide Hydrochloride— Increased risk of CNS depression; avoid concomitant use and monitor for adverse reactions.
Major (10)
- Cns Depressants + Butalbital, Acetaminophen And Caffeine— Other CNS depressants may enhance effects causing increased CNS depression.
- Cns Depressants + Butalbital, Aspirin, And Caffeine— Butalbital causes increased CNS depression when combined with other CNS depressants.
- Cns Depressants + Clonidine Hydrochloride— Potentiate sedating effects of clonidine. Avoid use.
- Cns Depressants + Daridorexant— Concomitant use of CNS depressants with daridorexant may lead to additive impairment of psychomotor performance and CNS …
- Cns Depressants + Doxylamine Succinate And Pyridoxine Hydrochloride— Concurrent use not recommended; severe drowsiness can occur. Includes hypnotic sedatives and tranquilizers.
- Cns Depressants + Haloperidol Decanoate— Haloperidol may potentiate CNS depressants including anesthetics, opioids, and alcohol.
- Cns Depressants + Metoclopramide— Increased risk of CNS depression. Avoid concomitant use and monitor for adverse reactions.
- Cns Depressants + Minocycline Hydrochloride— Potentially serious drug interactions may occur when intravenous magnesium sulfate is given concomitantly with CNS depre…
- Cns Depressants + Sodium Oxybate— May potentiate the CNS-depressant effects of sodium oxybate; use caution.
- Cns Depressants + Triazolam— Triazolam produces additive CNS depressant effects when co-administered with other CNS depressants.
Moderate (13)
- Cns Depressants + Baclofen— Additive CNS depression when used concomitantly, including drowsiness and sedation.
- Cns Depressants + Butalbital And Acetaminophen— Other CNS depressants may enhance the CNS depressant effects of butalbital and acetaminophen.
- Cns Depressants + Clobazam— Concomitant use increases risk of sedation and somnolence; effects may be potentiated.
- Cns Depressants + Doxepin— Sedative effects of CNS depressants may be potentiated when taken with doxepin.
- Cns Depressants + Doxepin Hydrochloride— Sedative effects of CNS depressants may be potentiated when taken with doxepin.
- Cns Depressants + Dronabinol— Additive CNS effects (dizziness, confusion, sedation, somnolence) may occur when taken concomitantly with dronabinol.
- Cns Depressants + Lacosamide— Concomitant use may cause CNS depression and cognitive/neuropsychiatric adverse reactions. Should be used with extreme c…
- Cns Depressants + Meclizine Hydrochloride— Concurrent use may result in increased CNS depression; monitor accordingly.
- Cns Depressants + Metaxalone— Concomitant use may increase risk of sedation and respiratory depression. Closely monitor for signs of respiratory depre…
- Cns Depressants + Metyrosine— Concurrent use with metyrosine can increase sedative effects of CNS depressants.
- Cns Depressants + Phenobarbital— Concomitant use may produce additive depressant effects when combined with sedatives, hypnotics, antihistamines, tranqui…
- Cns Depressants + Phenobarbital Sodium— Increased risk of sedation and respiratory depression with concomitant use. Closely monitor for adverse effects.
- Cns Depressants + Topiramate— Should be used with extreme caution due to potential CNS depression and cognitive/neuropsychiatric adverse reactions.