Systemic quinolone administration enhances the effects of oral anticoagulant warfarin and its derivatives.
Source: NLP:ofloxacin ophthalmic solution usp, 0.3%
Ofloxacin Ophthalmic Solution Usp, 0.3% Interactions
Brand names: Ofloxacin
Quinolone Antimicrobial
Route: Ophthalmic
Contraindications
CONTRAINDICATIONS Ofloxacin ophthalmic solution is contraindicated in patients with a history of hypersensitivity to ofloxacin, to other quinolones, or to any of the components in this medication ( see Warnings ).
Pregnancy & Breastfeeding
Pregnancy Teratogenic Effects Ofloxacin has been shown to have an embryocidal effect in rats and in rabbits when given in doses of 810 mg/kg/day (equivalent to 9000 times the maximum recommended daily ophthalmic dose) and 160 mg/kg/day (equivalent to 1800 times the maximum recommended daily ophthalmic dose). These dosages resulted in decreased fetal body weight and increased fetal mortality in rats and rabbits, respectively. Minor fetal skeletal variations were reported in rats receiving doses of 810 mg/kg/day. Ofloxacin has not been shown to be teratogenic at doses as high as 810 mg/kg/day and 160 mg/kg/day when administered to pregnant rats and rabbits, respectively. Nonteratogenic Effects Additional studies in rats with doses up to 360 mg/kg/day during late gestation showed no adverse effect on late fetal development, labor, delivery, lactation, neonatal viability, or growth of the newborn. There are, however, no adequate and well-controlled studies in pregnant women. Ofloxacin ophthalmic solution should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
5 interactions on record
Systemic quinolone administration interferes with the metabolism of caffeine.
Source: NLP:ofloxacin ophthalmic solution usp, 0.3%
Concomitant systemic quinolone administration is associated with transient elevations in serum creatinine.
Source: NLP:ofloxacin ophthalmic solution usp, 0.3%
Systemic quinolone administration has been shown to elevate plasma concentrations of theophylline.
Source: NLP:ofloxacin ophthalmic solution usp, 0.3%
Drug Interactions Specific drug interaction studies have not been conducted with ofloxacin ophthalmic solution.
Source: FDA drug label - ofloxacin ophthalmic solution usp, 0.3%