Nabilone has 22 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Alcohol, Amitriptyline, Amoxapine. Patients taking Nabilone should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 22
- Moderate
- 22
Moderate (22)
- Nabilone + Alcohol— Additive CNS depressant effects; increases positive subjective mood effects. Caution must be used when administering nab…
- Nabilone + Amitriptyline— Additive tachycardia, hypertension, and drowsiness reported with concurrent use.
- Nabilone + Amoxapine— Additive tachycardia, hypertension, and drowsiness reported with concurrent use.
- Nabilone + Amphetamine— Additive hypertension, tachycardia, and possibly cardiotoxicity reported with concurrent use.
- Nabilone + Antihistamines— Additive or super-additive tachycardia, drowsiness, and CNS depression reported with concurrent use.
- Nabilone + Antipyrine— Decreased clearance of antipyrine reported, presumably via competitive inhibition of metabolism.
- Nabilone + Atropine— Additive or super-additive tachycardia and drowsiness reported with concurrent use.
- Nabilone + Barbiturates— Additive drowsiness and CNS depression reported with concurrent use. Caution advised.
- Nabilone + Buspirone— Additive drowsiness and CNS depression reported with concurrent use.
- Nabilone + Cocaine— Additive hypertension, tachycardia, and possibly cardiotoxicity reported with concurrent use.
- Nabilone + Codeine— Additive CNS depressant effects observed in clinical study. Caution must be used when administering nabilone in combinat…
- Nabilone + Desipramine— Additive tachycardia, hypertension, and drowsiness reported with concurrent use.
- Nabilone + Diazepam— Additive CNS depressant effects; psychomotor function particularly impaired with concurrent use. Caution must be used wh…
- Nabilone + Disulfiram— A reversible hypomanic reaction was reported; confirmed by dechallenge and rechallenge.
- Nabilone + Fluoxetine— Hypomanic symptoms reported in a patient on fluoxetine who smoked marijuana; symptoms resolved after 4 days.
- Nabilone + Lithium— Additive drowsiness and CNS depression reported with concurrent use.
- Nabilone + Muscle Relaxants— Additive drowsiness and CNS depression reported with concurrent use.
- Nabilone + Naltrexone— Oral THC effects were enhanced by opioid receptor blockade.
- Nabilone + Nitrazepam— Additive drowsiness and CNS depression reported with concurrent use. Caution advised.
- Nabilone + Scopolamine— Additive or super-additive tachycardia and drowsiness reported with concurrent use.
- Nabilone + Sodium Secobarbital— Additive CNS depressant effects observed in clinical study. Caution must be used when administering nabilone in combinat…
- Nabilone + Theophylline— Increased theophylline metabolism reported with smoking of marijuana; effect similar to that following smoking tobacco.