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Demeclocycline

Route: Oral

9 interactions on record

Demeclocycline has 9 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Methoxyflurane, Penicillin, Tetracycline. Patients taking Demeclocycline should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 9
Contraindicated: 1
Major: 2
Moderate: 6

Contraindicated (1)

Demeclocycline + Methoxyflurane— Concurrent use of tetracyclines and methoxyflurane has been reported to result in fatal renal toxicity.

Major (2)

Demeclocycline + Penicillin— Since bacteriostatic drugs may interfere with the bactericidal action of penicillins, it is advisable to avoid giving te…
Demeclocycline + Tetracycline— Drug Interactions Because tetracyclines have shown to depress plasma prothrombin activity, patients who are on anticoagu…

Moderate (6)

Demeclocycline + Antacids Containing Calcium, Magnesium, Or Aluminum— Absorption of tetracyclines is impaired by antacids containing aluminum, calcium or magnesium.
Demeclocycline + Iron-Containing Preparations— Absorption of tetracyclines is impaired by iron-containing preparations.
Demeclocycline + Oral Anticoagulants— Tetracyclines depress plasma prothrombin activity; patients on anticoagulant therapy may require downward adjustment of …
Demeclocycline + Oral Contraceptives— Concurrent use of tetracyclines with oral contraceptives may render oral contraceptives less effective.
Demeclocycline + Vasopressin— Suspected of causing diabetes insipidus; may decrease pressor and antidiuretic effects of vasopressin. Hemodynamic monit…
Demeclocycline + Vasopressin In 0.9% Sodium Chloride— May cause diabetes insipidus, decreasing pressor and antidiuretic effects of vasopressin. Hemodynamic monitoring recomme…

Demeclocycline + Methoxyflurane⛔Contraindicated

Concurrent use of tetracyclines and methoxyflurane has been reported to result in fatal renal toxicity.

Demeclocycline + Penicillin⚠️Major

Since bacteriostatic drugs may interfere with the bactericidal action of penicillins, it is advisable to avoid giving tetracycline-class drugs in conjunction with penicillin.

Demeclocycline + Tetracycline⚠️Major

Drug Interactions Because tetracyclines have shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. Since bacteriostatic drugs may interfere with the bactericidal action of penicillins, it is advisable to avoid giving tetracycline-class drugs in conjunction with penicillin. Concurrent use of tetracyclines with oral contraceptives may render oral contraceptives less effective.

Demeclocycline + Antacids Containing Calcium, Magnesium, Or Aluminum🟡Moderate

Absorption of tetracyclines is impaired by antacids containing aluminum, calcium or magnesium.

Demeclocycline + Iron-Containing Preparations🟡Moderate

Absorption of tetracyclines is impaired by iron-containing preparations.

Demeclocycline + Oral Anticoagulants🟡Moderate

Tetracyclines depress plasma prothrombin activity; patients on anticoagulant therapy may require downward adjustment of anticoagulant dosage.

Demeclocycline + Oral Contraceptives🟡Moderate

Concurrent use of tetracyclines with oral contraceptives may render oral contraceptives less effective.

Demeclocycline + Vasopressin🟡Moderate

Suspected of causing diabetes insipidus; may decrease pressor and antidiuretic effects of vasopressin. Hemodynamic monitoring recommended.

Demeclocycline + Vasopressin In 0.9% Sodium Chloride🟡Moderate

May cause diabetes insipidus, decreasing pressor and antidiuretic effects of vasopressin. Hemodynamic monitoring recommended; adjust vasopressin dose as needed.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.