Tenofovir Disoproxil Fumarate has 21 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Adefovir Dipivoxil, Atazanavir, Darunavir. Patients taking Tenofovir Disoproxil Fumarate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 21
- Contraindicated
- 1
- Major
- 4
- Moderate
- 13
- Minor
- 2
Contraindicated (1)
- Tenofovir Disoproxil Fumarate + Adefovir Dipivoxil— Tenofovir disoproxil fumarate should not be administered in combination with adefovir dipivoxil in the treatment of chro…
Major (4)
- Tenofovir Disoproxil Fumarate + Atazanavir— Coadministration decreases atazanavir concentrations. Atazanavir must be given with ritonavir when coadministered with t…
- Tenofovir Disoproxil Fumarate + Darunavir— Coadministration increases tenofovir concentrations. Monitor for evidence of tenofovir toxicity.
- Tenofovir Disoproxil Fumarate + Didanosine— Tenofovir disoproxil fumarate increases didanosine concentrations, potentiating didanosine-associated adverse reactions …
- Tenofovir Disoproxil Fumarate + Lopinavir And Ritonavir— Coadministration increases tenofovir concentrations. Monitor for evidence of tenofovir toxicity.
Moderate (13)
- Tenofovir Disoproxil Fumarate + Acyclovir— Coadministration may increase tenofovir concentrations due to active tubular secretion competition. Monitor for evidence…
- Tenofovir Disoproxil Fumarate + Cidofovir— Coadministration may increase tenofovir concentrations due to active tubular secretion competition. Monitor for evidence…
- Tenofovir Disoproxil Fumarate + Ganciclovir— Coadministration may increase tenofovir concentrations due to active tubular secretion competition. Monitor for evidence…
- Tenofovir Disoproxil Fumarate + Gentamicin— Coadministration may increase tenofovir concentrations due to active tubular secretion competition. Monitor for evidence…
- Tenofovir Disoproxil Fumarate + Ledipasvir— Hepatitis C Antiviral Agents: sofosbuvir/velpatasvir sofosbuvir/velpatasvir/ voxilaprevir ledipasvir/sofosbuvir ↑ tenofo…
- Tenofovir Disoproxil Fumarate + Lopinavir— HIV-1 Protease Inhibitors : atazanavir lopinavir/ritonavir atazanavir/ritonavir darunavir/ritonavir ↓ atazanavir ↑ tenof…
- Tenofovir Disoproxil Fumarate + Ritonavir— When coadministered with tenofovir disoproxil fumarate, use atazanavir given with ritonavir. HIV-1 Protease Inhibitors :…
- Tenofovir Disoproxil Fumarate + Sofosbuvir— Hepatitis C Antiviral Agents: sofosbuvir/velpatasvir sofosbuvir/velpatasvir/ voxilaprevir ledipasvir/sofosbuvir ↑ tenofo…
- Tenofovir Disoproxil Fumarate + Tenofovir— 7 DRUG INTERACTIONS Tenofovir disoproxil fumarate increases didanosine concentrations. ( 7.2 ) Coadministration of VIREA…
- Tenofovir Disoproxil Fumarate + Valacyclovir— Coadministration may increase tenofovir concentrations due to active tubular secretion competition. Monitor for evidence…
- Tenofovir Disoproxil Fumarate + Valganciclovir— Coadministration may increase tenofovir concentrations due to active tubular secretion competition. Monitor for evidence…
- Tenofovir Disoproxil Fumarate + Velpatasvir— Hepatitis C Antiviral Agents: sofosbuvir/velpatasvir sofosbuvir/velpatasvir/ voxilaprevir ledipasvir/sofosbuvir ↑ tenofo…
- Tenofovir Disoproxil Fumarate + Voxilaprevir— Hepatitis C Antiviral Agents: sofosbuvir/velpatasvir sofosbuvir/velpatasvir/ voxilaprevir ledipasvir/sofosbuvir ↑ tenofo…
Minor (2)
- Tenofovir Disoproxil Fumarate + Entecavir— Coadministration did not result in significant drug interactions.
- Tenofovir Disoproxil Fumarate + Entecavir Anhydrous— Coadministration with entecavir did not result in significant drug interactions.