Olsalazine has 3 known drug interactions based on U.S. FDA drug labeling data. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Mercaptopurine, Azathioprine, Thioguanine. Patients taking Olsalazine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 3
- Major
- 1
- Moderate
- 2
Major (1)
- Olsalazine + Mercaptopurine— May inhibit TPMT enzyme, increasing risk of myelosuppression when coadministered with mercaptopurine. Use lowest possibl…
Moderate (2)
- Olsalazine + Azathioprine— Aminosalicylate derivative inhibits TPMT enzyme. Concomitant use should be done with caution.
- Olsalazine + Thioguanine— Inhibits TPMT enzyme; should be administered with caution to patients receiving concurrent thioguanine therapy.