Olsalazine

Also known as: Dipentum

3 interactions on record

Olsalazine has 3 known drug interactions based on U.S. FDA drug labeling data. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Mercaptopurine, Azathioprine, Thioguanine. Patients taking Olsalazine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 3
Major: 1
Moderate: 2

Major (1)

Olsalazine + Mercaptopurine— May inhibit TPMT enzyme, increasing risk of myelosuppression when coadministered with mercaptopurine. Use lowest possibl…

Moderate (2)

Olsalazine + Azathioprine— Aminosalicylate derivative inhibits TPMT enzyme. Concomitant use should be done with caution.
Olsalazine + Thioguanine— Inhibits TPMT enzyme; should be administered with caution to patients receiving concurrent thioguanine therapy.

Olsalazine + Mercaptopurine⚠️Major

May inhibit TPMT enzyme, increasing risk of myelosuppression when coadministered with mercaptopurine. Use lowest possible doses and monitor frequently for myelosuppression.

Olsalazine + Azathioprine🟡Moderate

Aminosalicylate derivative inhibits TPMT enzyme. Concomitant use should be done with caution.

Olsalazine + Thioguanine🟡Moderate

Inhibits TPMT enzyme; should be administered with caution to patients receiving concurrent thioguanine therapy.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.