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Micafungin

Also known as: Micafungin

Echinocandin Antifungal

Route: Intravenous

7 interactions on record

Micafungin has 7 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Itraconazole, Nifedipine, Rapamycin. Patients taking Micafungin should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 7
Moderate: 3

Moderate (3)

Micafungin + Itraconazole— 7 DRUG INTERACTIONS Monitor for sirolimus, itraconazole or nifedipine toxicity and dosage of sirolimus, itraconazole or …
Micafungin + Nifedipine— 7 DRUG INTERACTIONS Monitor for sirolimus, itraconazole or nifedipine toxicity and dosage of sirolimus, itraconazole or …
Micafungin + Rapamycin— Micafungin increases sirolimus AUC by 21%. Monitor for sirolimus toxicity and reduce dosage if necessary.

Micafungin + Itraconazole🟡Moderate

7 DRUG INTERACTIONS Monitor for sirolimus, itraconazole or nifedipine toxicity and dosage of sirolimus, itraconazole or nifedipine should be reduced, if necessary. ( 7 ) 7.1 Effect of Other Drugs on Micafungin CYP3A4, CYP2C9 and CYP2C19 Inhibitors Co-administration of micafungin with cyclosporine, itraconazole, voriconazole and fluconazole did not alter the pharmacokinetics of micafungin. Itraconazole AUC and C max were increased by 22% and 11%, respectively.

Micafungin + Nifedipine🟡Moderate

7 DRUG INTERACTIONS Monitor for sirolimus, itraconazole or nifedipine toxicity and dosage of sirolimus, itraconazole or nifedipine should be reduced, if necessary. Co-administration of Micafungin with Other Drugs Co-administration of micafungin with mycophenolate mofetil (MMF), amphotericin B, tacrolimus, prednisolone, sirolimus and nifedipine did not alter the pharmacokinetics of micafungin. Nifedipine AUC and C max were increased by 18% and 42%, respectively, in the presence of steady-state micafungin compared with nifedipine alone.

Micafungin + Rapamycin🟡Moderate

Micafungin increases sirolimus AUC by 21%. Monitor for sirolimus toxicity and reduce dosage if necessary.

Micafungin + Fluconazoleℹ️Unknown

( 7 ) 7.1 Effect of Other Drugs on Micafungin CYP3A4, CYP2C9 and CYP2C19 Inhibitors Co-administration of micafungin with cyclosporine, itraconazole, voriconazole and fluconazole did not alter the pharmacokinetics of micafungin. 7.2 Effect of Micafungin on Other Drugs CYP3A4 Substrates There was no effect of single or multiple doses of micafungin on cyclosporine, tacrolimus, prednisolone, voriconazole and fluconazole pharmacokinetics.

Micafungin + Prednisoloneℹ️Unknown

Co-administration of Micafungin with Other Drugs Co-administration of micafungin with mycophenolate mofetil (MMF), amphotericin B, tacrolimus, prednisolone, sirolimus and nifedipine did not alter the pharmacokinetics of micafungin. 7.2 Effect of Micafungin on Other Drugs CYP3A4 Substrates There was no effect of single or multiple doses of micafungin on cyclosporine, tacrolimus, prednisolone, voriconazole and fluconazole pharmacokinetics.

Micafungin + Ritonavirℹ️Unknown

CYP2C19 and CYP3A4 Inducer Co-administration of micafungin with rifampin and ritonavir did not alter the pharmacokinetics of micafungin.

Micafungin + Voriconazoleℹ️Unknown

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.