Profound hypotensive episodes may occur when diazoxide injection and hydralazine are used concomitantly. Continuous observation required.
Source: NLP:hydralazine hydrochloride
Diazoxide Interactions
Brand names: Diazoxide
Route: Oral
Contraindications
CONTRAINDICATIONS Diazoxide oral suspension is contraindicated in patients with: Functional hypoglycemia Hypersensitivity to diazoxide, any of the excipients in diazoxide oral suspension, or other thiazides
13 interactions on record
Concomitant administration may result in loss of seizure control.
Source: NLP:diazoxide
Concurrent use with sodium phosphate may result in hypernatremia.
Source: NLP:dibasic sodium phosphate, monobasic potassium phosphate and monobasic sodium phosphate
The hyperglycemic effect of diazoxide may be enhanced by thiazide component.
Source: NLP:candesartan cilexetil and hydrochlorothiazide
Diazoxide + Fosphenytoin SodiumModerate
May decrease phenytoin serum levels; dose adjustment may be required.
Source: NLP:fosphenytoin sodium
Diazoxide + GlimepirideModerate
May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.
Source: NLP:glimepiride
Diazoxide is highly bound to serum proteins and may displace bilirubin, resulting in higher blood levels of bilirubin.
Source: NLP:diazoxide
Diazoxide + Oral AnticoagulantsModerate
Diazoxide is highly bound to serum proteins and may displace coumarin, resulting in higher blood levels of coumarin.
Source: NLP:diazoxide
Diazoxide + Phenytoin SodiumModerate
May decrease phenytoin serum levels; monitoring of phenytoin levels recommended.
Source: NLP:extended phenytoin sodium
Concurrent use with sodium phosphate may result in hypernatremia.
Source: NLP:potassium phosphate, monobasic and sodium phosphate, monobasic, anhydrous
Diazoxide + RaloxifeneModerate
Use with caution; raloxifene is highly protein-bound and may affect protein binding of diazoxide.
Source: NLP:raloxifene
Use with caution. Highly protein-bound drug; raloxifene is >95% protein-bound and may affect protein binding of diazoxide.
Source: NLP:raloxifene hydrochloride
Diazoxide + ThiazidesModerate
Concomitant administration may potentiate the hyperglycemic and hyperuricemic effects of diazoxide.
Source: NLP:diazoxide