Diazoxide has 13 known drug interactions based on U.S. FDA drug labeling data. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Hydralazine Hydrochloride, Phenytoin, Sodium Phosphate, Dibasic, Anhydrous, Potassium Phosphate, Monobasic, And Sodium Phosphate, Monobasic, Monohydrate. Patients taking Diazoxide should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 13
- Major
- 3
- Moderate
- 10
Major (3)
- Diazoxide + Hydralazine Hydrochloride— Profound hypotensive episodes may occur when diazoxide injection and hydralazine are used concomitantly. Continuous obse…
- Diazoxide + Phenytoin— Concomitant administration may result in loss of seizure control.
- Diazoxide + Sodium Phosphate, Dibasic, Anhydrous, Potassium Phosphate, Monobasic, And Sodium Phosphate, Monobasic, Monohydrate— Concurrent use with sodium phosphate may result in hypernatremia.
Moderate (10)
- Diazoxide + Candesartan Cilexetil And Hydrochlorothiazide— The hyperglycemic effect of diazoxide may be enhanced by thiazide component.
- Diazoxide + Fosphenytoin Sodium— May decrease phenytoin serum levels; dose adjustment may be required.
- Diazoxide + Glimepiride— May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.
- Diazoxide + Iron-Containing Preparations— Diazoxide is highly bound to serum proteins and may displace bilirubin, resulting in higher blood levels of bilirubin.
- Diazoxide + Oral Anticoagulants— Diazoxide is highly bound to serum proteins and may displace coumarin, resulting in higher blood levels of coumarin.
- Diazoxide + Phenytoin Sodium— May decrease phenytoin serum levels; monitoring of phenytoin levels recommended.
- Diazoxide + Potassium Phosphate, Monobasic And Sodium Phosphate, Monobasic, Anhydrous— Concurrent use with sodium phosphate may result in hypernatremia.
- Diazoxide + Raloxifene— Use with caution; raloxifene is highly protein-bound and may affect protein binding of diazoxide.
- Diazoxide + Raloxifene Hydrochloride— Use with caution. Highly protein-bound drug; raloxifene is >95% protein-bound and may affect protein binding of diazoxid…
- Diazoxide + Thiazides— Concomitant administration may potentiate the hyperglycemic and hyperuricemic effects of diazoxide.