Diphenhydramine has 12 known drug interactions based on U.S. FDA drug labeling data. 5 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Adrenalin (Epinephrine), Epinephrine, Epinephrine 0.15 Pediatrics. Patients taking Diphenhydramine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 12
- Major
- 5
- Moderate
- 7
Major (5)
- Diphenhydramine + Adrenalin (Epinephrine)— Certain antihistamines, notably diphenhydramine, may potentiate the effects of epinephrine.
- Diphenhydramine + Epinephrine— Diphenhydramine potentiates the effects of epinephrine.
- Diphenhydramine + Epinephrine 0.15 Pediatrics— Effects of epinephrine may be potentiated by the antihistamine diphenhydramine.
- Diphenhydramine + Epinephrine 0.3 Adults— Effects of epinephrine may be potentiated by diphenhydramine.
- Diphenhydramine + Isoproterenol Hydrochloride— Antihistamine that may potentiate clinical response of isoproterenol.
Moderate (7)
- Diphenhydramine + Albuterol Sulfate— Diphenhydramine potentiates the effects of epinephrine.
- Diphenhydramine + Auvi-Q— Antihistamine that may potentiate the effects of epinephrine.
- Diphenhydramine + Dermatophagoides Farinae— First-generation H1-histamine receptor blocker that suppresses histamine skin test reactions and could mask positive res…
- Diphenhydramine + Flibanserin— Concomitant use may increase risk of CNS depression including somnolence.
- Diphenhydramine + Metoprolol— Potent CYP2D6 inhibitor may increase plasma concentration of metoprolol, decreasing cardioselectivity.
- Diphenhydramine + Metoprolol Tartrate— Potent CYP2D6 inhibitor may increase metoprolol plasma concentration, decreasing cardioselectivity.
- Diphenhydramine + Metoprolol Tartrate And Hydrochlorothiazide— Potent CYP2D6 inhibitor may increase plasma concentration of metoprolol; caution should be exercised.